Rilpivirine

This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.

Brand Names: US

Edurant

Brand Names: Canada

Edurant

What is this drug used for?

  • It is used to treat HIV infection.
  • This drug is taken with other drugs. Be sure you know about the warnings, benefits, and risks of these other drugs. Talk with the doctor if you have questions or concerns about any of the drugs.

What do I need to tell the doctor BEFORE my child takes this drug?

  • If your child is allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell the doctor about the allergy and what signs your child had.
  • If your child is taking any of these drugs: Carbamazepine, delavirdine, dexamethasone, dexlansoprazole, efavirenz, esomeprazole, etravirine, lansoprazole, nevirapine, omeprazole, oxcarbazepine, pantoprazole, phenobarbital, phenytoin, rabeprazole, rifampin, rifapentine, or St. John’s wort.
  • If the patient is a child younger than 12 years of age. Do not give this drug to a child younger than 12 years of age.
  • If your child weighs less than 77 pounds (35 kilograms).
  • If your child is pregnant, may become pregnant, or is breast-feeding a baby. Before giving this drug to your child, you will need to talk about the benefits and risks to your child and the baby. You will also need to talk about the best way for your child to prevent passing HIV to the baby.

This is not a list of all drugs or health problems that interact with this drug.

Tell the doctor and pharmacist about all of your child’s drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe to give this drug with all of your child’s other drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.

What are some things I need to know or do while my child takes this drug?

  • Tell all of your child’s health care providers that your child is taking this drug. This includes your child’s doctors, nurses, pharmacists, and dentists.
  • High cholesterol has happened with this drug. If you have questions, talk with the doctor.
  • Have your child’s blood work and other lab tests checked as you have been told by the doctor.
  • This drug is not a cure for HIV. Keep giving this drug to your child as you have been told by the doctor or other health care provider, even if your child feels well. Be sure your child stays under the care of the doctor and has regular appointments.
  • This drug helps to lower how much HIV is in the blood. Lowering the amount of HIV in the blood until it is not detected on blood tests can help lower the risk of spreading HIV to others. There are also other ways to help prevent the spread of HIV to others. This includes using condoms during sex and not sharing needles and other injection equipment. Talk with your child’s doctor or other health care provider about the best way to prevent spreading HIV to others.
  • Do not give your child more of this drug than what the doctor told you to give. Giving more of this drug than you are told may raise the chance of severe side effects.
  • Certain drugs or herbal products could cause this drug to not work as well. Be sure your child’s doctor and pharmacist know about all of your child’s drugs.

What are some side effects that I need to call my child’s doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of depression, suicidal thoughts, emotional ups and downs, abnormal thinking, anxiety, or lack of interest in life.
  • A heartbeat that does not feel normal.
  • Muscle or joint pain.
  • Feeling very tired or weak.
  • Changes in your child’s immune system can happen when your child starts taking drugs to treat HIV. If your child has an infection that you did not know was there, it may show up when your child takes this drug. Tell your child’s doctor right away if your child has any new signs after starting this drug, even after taking it for several months. This includes signs of infection like fever, sore throat, weakness, cough, or shortness of breath.
  • Severe skin and allergic reactions have happened with this drug. Skin reactions have happened along with fever or problems in body organs like the liver. Call the doctor right away if your child has red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; sores in the mouth, throat, nose, or eyes; trouble swallowing; or signs of liver problems like dark urine, tiredness, decreased appetite, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away:

  • Headache.
  • Trouble sleeping.
  • Feeling dizzy or sleepy.
  • Upset stomach or throwing up.
  • Stomach pain.

These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.

You may report side effects to your national health agency.

How is this drug best given?

Give this drug as ordered by your child’s doctor. Read all information given to you. Follow all instructions closely.

  • Give this drug at the same time of day.
  • Give with a meal.
  • Do not use a protein drink in place of a meal.
  • It is important that your child does not miss or skip a dose of this drug during treatment.
  • Do not give antacids within 2 hours before this drug or 4 hours after this drug.
  • If your child takes other drugs, they may need to be given at a different time than this drug. Check with the doctor or pharmacist about the best time to give them.

What do I do if my child misses a dose?

  • Give a missed dose as soon as you think about it, with a meal.
  • If it has been 12 hours or more since the missed dose, skip the missed dose and go back to your child’s normal time.
  • Do not give 2 doses at the same time or extra doses.
  • If you are not sure what to do if your child misses a dose, call the doctor.

How do I store and/or throw out this drug?

  • Store at room temperature in a dry place. Do not store in a bathroom.
  • Store in the original container to protect from light.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

General drug facts

  • If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
  • Do not share your child’s drug with others and do not give anyone else’s drug to your child.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider’s examination and assessment of a patient’s specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last Reviewed Date

2022-11-08

Copyright

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Last Updated

Monday, December 12, 2022