Next-generation Genetic Association Studies: Challenges and Opportunities


There are several challenges in the transition from single-marker tests on common SNPs in genome-wide association studies to set-based inference on all variants in a functional element, with genotypes called from second-generation sequencing data. Dan Nicolae will present a framework for the analysis of sequence data where we harness population genetics theory to provide prior information on effect sizes that allows a general and powerful test for association. He will also  discuss some of the challenges in this transition, including: (i) the construction of sets; (ii) the implicit and explicit assumptions on underlying genetic models of risk for a given set; (iii) interactions with environment and ancestry; and (iv) the interpretation of results.


This program is open to all.

Date & Time(s)


Memorial Sloan Kettering Cancer Center
307 East 63rd Street
Room 331
New York, NY 10065


Biostatistics Seminar Series
Department of Epidemiology and Biostatistics
Memorial Sloan Kettering Cancer Center


Dan Nicolae, PhD
Departments of Medicine, Statistics and Human Genetics
The University of Chicago