Carrie Ann Adelman
Analysis of Mre11 Complex Roles in Response to Physiological Sources of DNA Damage in the Mouse
Faculty Mentor: John Petrini, PhD
Claudio Alarcon
Role of the Linker Region of Smad Proteins in the Regulation of the TGF-beta and BMP Signaling Pathways
Faculty Mentor: Joan Massagué, PhD
Jideofor Aniukwu*
The Pathways and Outcomes of Mycobacterial NHEJ Depend on the Structure of the Broken DNA Ends
Faculty Mentor: Stewart Shuman, MD, PhD, and Michael Glickman, MD
Eli Berdougo
Human Cdc14 Phosphatases Are Not Essential for Viability and Do Not Regulate Mitotic Exit
Faculty Mentor: Prasad Jallepalli, MD, PhD
Zhenjian Cai
Structural Studies of the Regulation of the DNA Damage Checkpoint Kinase Chk2
Faculty Mentor: Nikola Pavletich, PhD
Zhucheng Chen
Mechanism of Homologous Recombination from Structures of RecA/Single-Stranded DNA and RecA/Double-Stranded DNA Filaments
Faculty Mentor: Nikola Pavletich, PhD
Server Adil Ertem
Catena: A Novel Cellular Entity Composed of Ovarian Cancer Stem Cells
Faculty Mentor: Malcolm Moore, DPhil
Zhonghua Gao
Regulation of the Molecular Machinery of Programmed Cell Death
Faculty Mentor: Xuejun Jiang, PhD
Jaclyn Caye Greimann
Structure and Biochemistry of the Eukaryotic RNA Exosome
Faculty Mentor: Christopher Lima, PhD
Ensar Halilovic
The Role of Mutational Activation of RAS and PI3K Signaling Pathways in Human Tumors: Biologic and Therapeutic Implications
Faculty Mentor: Neal Rosen, MD, PhD
Ting Jia
Analysis of CC-Chemokines and Monocyte Trafficking in Innate Immune Defense Against Listeria Monocytogenes
Faculty Mentor: Eric Pamer, MD
Lucy Willis Kappel
The Role of Th17-Related Cytokines in Murine Graft-Versus-Host Disease
Faculty Mentor: Marcel van den Brink, MD, PhD
Nirsoshika Ashanthi Keppetipola
Biological and Biochemical Specificities of Binuclear Metallophosphoesterases
Faculty Mentor: Stewart Shuman, MD, PhD
John Charles Markley*
Tumor-Specific Human Primary T Cells Engineered to Overexpress IL-2, IL-7, IL-15, or IL-21 Confer Varying Degrees of Tumor Rejection and Xenogeneic Graft-Versus-Host Disease in an Immunodeficient Mouse Model
Faculty Mentor: Michel Sadelain, MD, PhD
Mohamed Firaz Mohideen
Biochemical and Structural Insights into SUMO Conjugation and Recognition
Faculty Mentor: Christopher Lima, PhD
Hyung-Song Nam*
The Molecular Identity of Neural Stem Cells: High Levels of Id1 Expression Defines B1 Type Adult Neural Stem Cells
Faculty Mentor: Robert Benezra, PhD
David Miguel Padua*
Identifying a Role for TGF-beta Signaling in Breast Cancer Metastasis to the Lungs
Faculty Mentor: Joan Massagué, PhD
Lisa M. Placanica
Endogenous Gamma Secretase: Activity, Substrate Selectivity, and Subunit Composition
Faculty Mentor: Yueming Li, PhD
Alejandro Ramirez
Analysis of RNA Phosphotransferase and tRNA Splicing Activities of Human Clp1
Faculty Mentor: Stewart Shuman, MD, PhD
Catherine Leah Randall
Genetic Dissection of Polo-like Kinase 1’s Functions in Human Cell Division
Faculty Mentor: Prasad Jallepalli, MD, PhD
Brian Edward Richardson
Actin Cytoskeleton Remodeling Is Essential for Myoblast Fusion in Drosophila
Faculty Mentor: Mary Baylies, PhD
Gabrielle Ann Rizzuto*
Self-Antigen Specific CD8+ T Cell Precursor Frequency Determines the Quality of the Anti-tumor Immune Response
Faculty Mentor: Alan Houghton, MD
Elizabeth Romero
Role of Id1 in Embryonic Stem Cell Self-Renewal and Differentiation
Faculty Mentor: Robert Benezra, PhD
Shiying Shang
A Unified Synthetic Approach to Polyketides Having Both Skeletal and Stereochemical Diversity
Faculty Mentor: Derek Tan, PhD
Christopher Chad Shelton
Gamma Secretase Regulation and Function in Alzheimer Disease and Non-Hodgkin’s Lymphoma
Faculty Mentor: Yueming Li, PhD
Barry Stephen Taylor
Integrative Characterization of Chromosomal Aberrations in Human Cancer
Faculty Mentor: Chris Sander, PhD
Olisambu Uche
The BTB-Zinc Finger Transcriptional Regulator, PLZF, Controls the
Development of iNKT Cell Innate Effector Functions
Faculty Mentor: Derek Sant’Angelo, PhD
Ming-Ching Wong
Regulation of Twist Activity During Mesoderm and Somatic Muscle Development in Drosophila
Faculty Mentor: Mary Baylies, PhD
Guozhou Xu
Crystal Structures of the Fanconi Anemia Proteins
Faculty Mentor: Nikola Pavletich, PhD
Kai Xu
Host Cell Recognition by Henipa-Virus: Crystal Structures of Henipa-Virus Attachment Glycoproteins and the Complexes with Receptors
Faculty Mentor: Dimitar Nikolov, PhD
Ali Asgar Yunus
Structural and Biochemical Studies of the Sumo Conjugation Pathway
Faculty Mentor: Christopher Lima, PhD
*MD/PhD