Women with Ovarian Cancer Benefit from Treatment at High-Volume Centers


More than 60 percent of women diagnosed with ovarian cancer may not be receiving the appropriate care for this aggressive disease, according to a study presented this week at the Society of Gynecologic Oncology annual meeting.

The study of more than 13,000 women, led by experts at the University of California Irvine Medical Center, showed that only 37 percent received treatment that met the guidelines of the National Comprehensive Cancer Network, a group of leading cancer centers that includes Memorial Sloan Kettering.

These women, who were typically cared for at high-volume hospitals by high-volume surgeons, also had better survival outcomes than those at institutions treating fewer women with ovarian cancer.

In an interview, Richard R. Barakat, Chief of Memorial Sloan Kettering’s Gynecology Service, commented on the study’s results and the extensive experience of Memorial Sloan Kettering’s ovarian cancer treatment team.

How did Memorial Sloan Kettering’s ovarian cancer experts react to the results of the study?

We were not surprised. We have known for many years that ovarian cancer should be operated on by experienced gynecologic oncologists – not by general surgeons or gynecologists – who are trained to perform the complex operations required to remove as much of the disease as possible.

At Memorial Sloan Kettering, we have more than 20 medical professionals dedicated exclusively to the treatment of ovarian and other gynecologic cancers. The volume of ovarian cancer procedures performed at Memorial Sloan Kettering also ranks among the highest in the country.

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What is the goal of Memorial Sloan Kettering gynecologic oncologists when removing ovarian cancer?

Our strategy is to remove as much of the cancer as possible – and whenever possible, to remove the cancer completely.

Our physicians and researchers have authored numerous scientific publications about our improved outcomes achieved by performing a procedure known as radical debulking for advanced disease. (1), (2) Radical debulking is a complex operation aimed at ideally leaving no significant amount of disease behind, or at most, no tumor that measures more than 5 millimeters.

This usually involves removing not only the ovaries but also the uterus, cervix, and fallopian tubes, as well as a portion of the intestines and any disease in the upper abdomen, including the diaphragm and the spleen.

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Another advanced treatment for ovarian cancer is chemotherapy delivered directly into the abdomen. How do you determine if and when this treatment is appropriate?

At Memorial Sloan Kettering, we are strong advocates for the use of intraperitoneal chemotherapy for the appropriate patients. This form of chemotherapy should be reserved for women who have had a successful debulking procedure with no disease remaining or who have remaining disease measuring less than 5 millimeters.

This treatment involves delivering chemotherapy directly into the internal lining of the abdominal area, known as the peritoneal cavity, through a surgically implanted catheter. It allows a high concentration of chemotherapy drugs to reach the cancerous tissue for a prolonged period of time.

Memorial Sloan Kettering pioneered the first clinical trials that evaluated intraperitoneal chemotherapy in the late 1980s, and we are one of the most experienced centers to offer this type of chemotherapy.

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What are the first steps a woman should take when diagnosed with ovarian cancer?

We recommend that women seek out a gynecologic oncologist who treats women with ovarian cancer on a regular basis. In addition, it is beneficial to be treated by a multidisciplinary team of surgeons and medical oncologists – like ours at Memorial Sloan Kettering – with extensive experience in using the most-advanced, effective techniques.

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Commenting is disabled for this blog post.

I do not have ovarian cancer but I do have Dr.Barakat and I thank God everyday for him and the wonderful staff at Memorial Sloan Kettering!

I was diagnosed in 2000 with Ovarian and Uterine Cancer. After 3 major surgeries...5 years apart.....I am alive and well. Thanks to Dr.Barakat and Dr.Lichtman. Two super doctors and human beings. I love them both.

I am living proof of the truth of the above article. In 1990, I was diagnosed with stage 4 ovarian cancer. Luckily, I was operated on and treated at MSKCC by Dr. Hoskins, Dr. Markman, and Dr. Barakat. After undergoing 6 months of extensive chemo, my second look surgery showed no cancer cells. However, the doctors still suggested that I undergo intraperitoneal treatment for 3 months, which I did. Thankfully, I have not had any recurrence of the disease, and still follow up with yearly check ups and a mammography at MSKCC.

What kind of work are you doing with GCT ovarian cancer? I was diagnosed a couple of years ago and it seems so little is known regarding reliable treatment, prognosis and recurrence rates and treatment in those instances. Thank you

Hi, I am in the early stages of diagnosis, and it was just discovered I have 2 blood clots on my lungs and leg; injecting lovenox now to clear. Would I be able to fly during this time to come to your center for treatment w the dvt? Thank you.

Dear Eliza, this is something you should discuss with your current doctor. Thank you for your comment and best wishes to you.

My daughter is stage 3 reoccurrence and waiting to be accepted to Sloane for her trial. .. we are anxiously waiting for her to begin ... xoxo to her doctors who mean so much to us !

Dear Donna, we’re sorry to hear about your daughter’s diagnosis. Thank you for your comment and best wishes to you and to her!

I know that your Dr. Mark Kris at MSK is utilizing "Watson" technology and I am wondering if Watson is being used at all within your department as it relates to Ovarian Cancer?

Dear Joe, rather than “using” Watson technology to make treatment decisions, experts at MSK, including Dr. Kris, are “training” Watson, so that doctors and patients at other institutions will be able to benefit from Memorial Sloan Kettering’s institutional knowledge. Thank you for your comment.

Would it be possible to find out approx time it would take to get I to an Ovarian Cancer Physican ? My sister in law has had a recurrence and seems to be spreading rapidly in the peritoneal cavity. Thank you

Dear Beth, we’re sorry to hear about your sister-in-law’s recurrence. We recommend that she call our Patient Access Service at 800-525-2225 and talk to someone there about making an appointment. Wait times are usually not long, but they can vary depending on things like the time to get records transferred and waiting for insurance approval (if applicable). The experts at that number should be able to answer her questions. Thank you for your comment, and best wishes to you and your sister-in-law.

I was diagnosed with stage 3 ovarian cancer in 2016, had 6 cycles of chemotherapy and full hysterectomy, there was no evidence of disease. After 11 month in July this year I had reoccurrence peritoneal, my gynecologist oncologist said that it is chronic, which means it will come back afterwards. At this stage I am going through 6 cycles of chemo cisplatin ang gemcitabine. I live in Melbourne, Australia.
I want to explore more options to get rid of this disease. Please advice further treatments and cost of it. I am happy to come there for the consultation.
kind regards
Kanwal Singh