Disease-Free Probability Following Surgery


Our disease-free probability nomogram is a tool designed to predict the likelihood of remaining free of colon cancer at five years and ten years after undergoing a complete resection (surgical removal of all cancerous tissue). It is appropriate for patients whose colon cancer had shown no evidence of metastasis, or spread beyond the colon, before surgery or at the time of surgery.

Results produced by this tool are based on data from patients treated at MSK, a large research institution with surgeons who perform a high volume of colon cancer procedures. All results must be understood in the context of each patient’s specific treatment plan. Patients and caregivers using this tool should discuss the result with the patient’s physician.

To gather the information required to use this nomogram, use our worksheet.

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All fields are required unless noted optional
years (20 to 99)
Note: This prediction tool is only for tumors found in the colon, between the pouch that forms the first part of the large intestine (known as the cecum) and the S-shaped section of the colon that connects to the rectum (the rectosigmoid, or sigmoid, colon).
ng/mL (0 to 90)
What is CEA?
Carcinoembryonic antigen (CEA) is a substance that may be found in the blood of people who have colon cancer, other types of cancer or diseases, or who smoke tobacco. CEA levels may help keep track of how well cancer treatments are working or if cancer has come back. It is a type of tumor marker.
Note: This prediction tool is only applicable for T stages T1 to T4. Indicating the substage by letter (e.g., a or b) is not required.
More on T staging
The T stages are part of the TNM Staging System, which uses TNM classifications to describe the extent of cancer in a patient's body. T describes the size of the tumor and whether it has invaded nearby tissue; N describes whether regional lymph nodes are involved and, if so, how extensively; and M describes whether distant metastasis (spread of cancer from one body part to another) is present. The system is maintained by the Union for International Cancer Control (UICC) and the American Joint Committee on Cancer (AJCC) and is updated periodically.
What is grade/differentiation?
Tumor grade/differentiation refers to the extent of abnormality of the cells when viewed under the microscope. Well-differentiated tumor cells resemble normal cells and tend to grow and spread at a slower rate than poorly differentiated or undifferentiated tumor cells.
Was there lymphovascular invasion (cancer present in the lymphatic or blood vessels)?
What is lymphovascular invasion?
Lymphovascular invasion means that cancer cells were found in the vessels of the colon (arteries, veins, and/or lymphatics).
Was there perineural invasion (cancer present in or around the nerves)?
What is perineural invasion?
Perineural invasion means that cancer cells were found in or around the nerves near the colon or rectum.
nodes (0 to 24)
What are lymph nodes?
Lymph nodes are rounded masses of tissue that act as filters for a fluid called lymph. Lymph nodes are located along lymphatic vessels, and they store lymphocytes (white blood cells).
nodes (0 to 42)
Did you receive chemotherapy after your surgery?
Note: Results produced by this tool are based on data from patients treated from 1990 to 2000, when fluorouracil was the only active agent in adjuvant chemotherapy for colon cancer.