Rose laurel, Adelfa, Rosenlorbeer, Karavira
How It Works
Oleandrin can inhibit the growth of some cancer cells, but it has yet to be shown to be an effective cancer treatment.
Oleandrin is an extract from the plant, Nerium oleander, which contains substances that are similar to the active chemical found in the heart medication, digoxin. In the laboratory, Anvirzel™, a brand of oleandrin, is able to suppress growth and cause cell death in certain cancer cell lines. It also has been seen to increase the sensitivity of prostate cancer cell lines to radiation therapy. However, it is unclear whether these effects occur in the human body. Oleandrin has also been used to treat heart disease, AIDS, and hepatitis.
- To treat cancer
Laboratory studies show some anticancer activity in cancer cell lines, but clinical trials have not evaluated the anticancer activities of oleandrin in humans.
There is no scientific evidence to support the following claims:
- To treat congestive heart failure
- To treat hepatitis C
- To treat AIDS
- The raw plant from which Anvirzel™ is extracted, Nerium oleander, is highly toxic. Consumption of only one Nerium oleander leaf may be fatal.
- Onset of toxicity occurs several hours after consumption and includes vomiting, abdominal pain, bluish skin discoloration, low blood pressure, low body temperature, dizziness, respiratory paralysis, and death.
Do Not Take If
- You are taking digoxin: Anvirzel™ contains cardiac glycosides, the same active chemical in digoxin, so the two medications may have an additive effects, causing toxicity.
- You are taking P-glycoprotein (P-gp) substrates drugs: Oleander leaf extract may increase the blood levels of these drugs.
- You have high blood levels of calcium
- You have low blood levels of potassium
- You have abnormally slow heart rate
- You have abnormally fast ventricular heart rate
- You have heart failure
Anvirzel™ contains the cardiac glycosides, the same active chemical in digoxin, and is therefore contraindicated in people with these conditions.
- Nausea and vomiting
- Pain at injection site
- Tumor pain
- Breast pain
- Abnormally high white blood cell counts
- Abnormally fast heart rate
- Cardiac arrhythmias
- Consumption of oleander leaves resulted in the death of an adult diabetic male. Oleandrin levels in the blood were roughly 10 ng/mL.
- Daily intramuscular injections of Nerium oleander extract for 2 months are suspected as probable cause of death of a 43-year-old patient with metastatic synovial sarcoma of the knee. Her symptoms included nausea, vomiting, severe stomach pain, and bloating followed by a gradual reduction of liver enzymes and cardiopulmonary arrest.
Anvirzel™ is considered an “investigational new drug” in the United States and is not available for use except under approved clinical trials. Until more test results showing this product is effective and safe are published, it should not be used outside of clinical trials.