Superoxide Dismutase

Purported Benefits, Side Effects & More
Share
This information describes the common uses of Superoxide Dismutase, how it works, and its possible side effects.
Tell your healthcare providers about any dietary supplements you’re taking, such as herbs, vitamins, minerals, and natural or home remedies. This will help them manage your care and keep you safe.

What is it?

Superoxide dismutase supplements have not been shown to confer any health benefits.

Superoxide dismutase (SOD) is an enzyme found in all cells of the human body. It breaks down superoxide radicals, which are toxic to living cells and cause DNA mutations, into harmless components consisting of oxygen and hydrogen peroxide. The theory behind taking SOD as a supplement is that it will confer extra protection against cellular and DNA damage, but this does not hold true because SOD cannot be absorbed into the bloodstream when taken orally.

What are the potential uses and benefits?

  • As an anti-aging supplement
    There is no research to back this claim.
  • To prevent bladder inflammation
    A few studies support the use of superoxide dismutase injections to prevent cystitis. More research is needed. No studies support the use of oral superoxide dismutase supplements for this use.
  • To reduce inflammation
    This claim has no supporting research.
  • To treat osteoarthritis
    One clinical trial supports the use of superoxide dismutase injections into the knee for osteoarthritis, but more research is needed. The long-term effectiveness and safety of such injections is not known.
  • To treat scleroderma
    No scientific evidence supports this use.
  • To treat urinary tract disorders
    There are no data to back this claim.