The MSK Pathology Review is designed to provide members of the department, alumni, and others in our academic community a snapshot of the activities ongoing in our department. Our discipline continues to evolve, and while we maintain the techniques that have remained the cornerstones of tumor diagnostics for much of our history, we are also excited about the many opportunities to expand the impact of the diagnostic information we provide. Now more than ever, pathology is at the center of the clinical management of patients with cancer, and our department will continue to lead the way in the development and assessment of novel tools to characterize this spectrum of human disease and to define the most effective therapies for our patients.