Molecular Pharmacology Program
The David Scheinberg Lab
Research
The overall goals of this laboratory are to develop novel targeted immunotherapies based on effectors of the immune system and to understand their mechanisms of action as well as the mechanisms of resistance to them. This includes antibodies, targeted nano-devices, engineered cells, and active specific agents such vaccines. An important goal is to take these new therapies into human clinical trials for testing. Examples include a molecular nanogenerator that releases alpha particles inside cancer cells, now being tested in Phase II human trials (Blood, 2010), and a vaccine to WT1 in Phase III trials. Read full article in Science.
We have developed targeted alpha particle therapies, targeted beta emitters, oncogenic protein peptide vaccines, humanized antibodies, each of which reached human clinical trials; More recently we have discovered TCR mimic antibodies to intracellular proteins (Science Trans. Med., 2013), (Nature Biotech., 2015), as well as prototype targeted nano-machines (Nature Nano, 2013), and cellular micropharmacies (Nature Chem.Biol., 2021).
Research Projects
Featured News
People
David A. Scheinberg, MD, PhD
Chair, Center for Experimental Therapeutics, MSK; Deputy Director, Sloan Kettering Institute, for Therapeutic Discovery
- Molecular Pharmacology Program Member David Scheinberg focuses on the discovery and development of novel, specific immunotherapeutic agents and targeted nanodevices for cancer therapy.
- MD, PhD, Johns Hopkins University School of Medicine
- [email protected]
- Email Address
- 646-888-2190
- Office Phone
- View physician profile
- Physician profile
Members
Research Assistant
Senior Research Scientist
Research Assistant
Laboratory Member
Graduate Student
Graduate Student
Research Fellow
Senior Administrative Assistant
Hematology/Oncology Fellow
Graduate Student
Senior Research Scientist
Research Technician
Graduate Student
Medical Student Research Fellow Education
Senior Research Scientist
Graduate Student
Graduate Student
Lab Alumni
Principal Scientific Communication Lead at Genentech, San Francisco, CA
Graduate Student
Research Fellow
Graduate Student
Graduate Student
Visiting Scientist
Graduate Student
Research Technician
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Research Technician
Research Technician
Lab Rotation SEP-DEC 2020
Graduate Student
Research Technician
Graduate Student
Research Assistant
Research Associate
Research Technician
Graduate Student
Research Fellow
Scientist
Pediatric Hematology/Oncology Fellow
Research Fellow
Research Assistant
Research Scholar
Lab Affiliations
- Molecular Pharmacology Program
- Department of Medicine
- Center for Experimental Therapeutics
- Center for Cell Engineering
- Geoffrey Beene Cancer Research Center
- Center for Molecular Imaging & Bioengineering
- Tri-Institutional PhD Program in Chemical Biology
- Gerstner Sloan Kettering Graduate School of Biomedical Sciences
