Education
Current Position
Associate Professor at Shanghai Jiao Tong University
Publications
Yu Y, Li S, Ser Z, Sanyal T, Choi K, Wan B, Kuang H, Sali A, Kentsis A, Patel DJ, Zhao X (2021). Integrative analysis reveals unique structural and functional features of the Smc5/6 complex. Proc Natl Acad Sci U S A. 118(19):e2026844118.
Li S, Bonner JN, Wan B, So S, Summers A, Gonzalez L, Xue X, Zhao X (2021). Esc2 orchestrates substrate-specific sumoylation by acting as a SUMO E2 cofactor in genome maintenance. Genes Dev. 35(3-4):261-272. doi: 10.1101/gad.344739.120. Epub 2021 Jan 14.
Wan B, Wu J, Meng X, Lei M, Zhao X. Molecular basis for control of diverse genome stability factors by the multi-BRCT scaffold Rtt107. Molecular Cell. 2019 Jul.
Wan B, Hang LE, Zhao X. Multi-BRCT scaffolds use distinct strategies to support genome maintenance. Cell Cycle. 2016 Oct;15(19):2561-2570. doi: 10.1080/15384101.2016.1218102. Epub 2016 Aug 11. Review. PubMed [PMID: 27580271]; PubMed Central PMCID: PMC5053572.
Bonner JN, Choi K, Xue X, Torres NP, Szakal B, Wei L, Wan B, Arter M, Matos J, Sung P, Brown GW, Branzei D, Zhao X. Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates. Cell Rep. 2016 Jul 12;16(2):368-378. doi: 10.1016/j.celrep.2016.06.015. Epub 2016 Jun 30. PubMed [PMID: 27373152]; PubMed Central PMCID: PMC5051638.
Chen, Y., Wan, B., Wang, K.C., Cao, F., Yang, Y., Protacio, A., Dou, Y., Chang, H.Y., and Lei, M. (2011). Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding. EMBO Reports 12, 797-803.
Huang, J., Gurung, B., Wan, B., Matkar, S., Veniaminova, N.A., Wan, K., Merchant, J.L., Hua, X., and Lei, M. (2012). The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature 482, 542-546.
Huang, J., Wan, B., Wu, L., Yang, Y., Dou, Y., and Lei, M. (2012). Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex. Cell Research 22, 1078-1081.
Sarkar, J., Wan, B., Yin, J., Vallabhaneni, H., Horvath, K., Kulikowicz, T., Bohr, V.A., Zhang, Y., Lei, M., and Liu, Y. (2015). SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates. Nucleic Acids Research 43, 5912-5923.
Wan, B., Tang, T., Upton, H., Shuai, J., Zhou, Y., Li, S., Chen, J., Brunzelle, J.S., Zeng, Z., Collins, K., et al. (2015). The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex. Nature Structural & Molecular Biology 22, 1023-1026.
Wan, B., Yin, J., Horvath, K., Sarkar, J., Chen, Y., Wu, J., Wan, K., Lu, J., Gu, P., Yu, E.Y., et al. (2013). SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. Cell Reports 4, 861-869.