Research Labs

Cancer biologist Robert Benezra studies the molecular mechanisms of tumor growth and metastatic progression using mouse models. In addition, he studies the spindle assembly checkpoint which ensures proper chromosome segregation and is often deregulated in cancer.

Physician-scientist Yu Chen studies the role of transcription factors that are critical for prostate cancer development.

The Choi Lab develops new synthetic biology tools to study cell-fate decisions in development.

Lydia Finley studies the mechanisms that link metabolic pathways to cell fate decisions.

Physician-scientist Karuna Ganesh studies stem cell plasticity in metastasis, therapy resistance and tissue regeneration.

The Hadjantonakis laboratory studies pluripotency, cell lineage commitment, tissue patterning, and morphogenesis in mammalian embryos and in stem cell and organoid models.

Physician-scientist Alan Hanash studies transplant immunology and immune-mediated mechanisms of tissue damage and regeneration.

The Huangfu laboratory uses human pluripotent stem cells (hPSCs) as a powerful genetic model to interrogate the transcriptional and epigenetic mechanisms underlying cell fate decisions in development and disease.

The Jasin laboratory focuses on double-strand break repair and genomic integrity in mammalian cells and the relationship to tumor suppression.

The Joyner laboratory studies the involvement of Hedgehog signaling and transcription factors in cerebellum development, regeneration and cancer.