Barry S. Taylor, PhD

Assistant Attending

Barry S. Taylor, PhD

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Dr. Taylor is an Assistant Member in the Human Oncology and Pathogenesis Program, Assistant Attending Computational Oncologist in the Department of Epidemiology and Biostatistics, and Associate Director of the Marie-Josée and Henry R. Kravis Center for Molecular Oncology. The goal of his laboratory research is to define the germline and somatic abnormalities that mediate the genesis, progression, and response to therapy of human cancers. His research program lies at the interface of computational and cancer biology, employing translational genomic and functional genetic approaches to identify tumor cell-specific vulnerabilities that can be therapeutically exploited in diverse malignancies. Dr. Taylor’s lab has been involved in many collaborative studies exploring the genomic basic of diverse human cancer types and the development of computational methodologies for cancer genome discovery. His current research centers on exploring the molecular and evolutionary origins of response and resistance to cancer therapy, and defining the mechanisms, serial genetic evolution, and both biological and therapeutic significance of common and rare driver mutations in tumorigenesis. The lab’s overall goal is to capitalize on population-scale and data-driven approaches to accelerate clinical translation in molecularly defined populations of cancer patients.


Selected peer-reviewed publications:

  1. Iyer G, Hanrahan AJ, Milowsky MI, Al-Ahmadie H, Scott SN, Janakiraman M, Pirun M, Sander C, Socci ND, Ostrovnaya I, Viale A, Heguy A, Peng L, Chan TA, Bochner B, Bajorin DF, Berger MF, Taylor BS, Solit DB. Genome sequencing identifies a basis for everolimus sensitivity. Science. 2012 Oct 12;338(6104):221. doi: 10.1126/science.1226344. Epub 2012 Aug 23. PubMed PMID: 22923433; PubMed Central PMCID: PMC3633467.

  2. Johnson BE, Mazor T, Hong C, Barnes M, Aihara K, McLean CY, Fouse SD, Yamamoto S, Ueda H, Tatsuno K, Asthana S, Jalbert LE, Nelson SJ, Bollen AW, Gustafson WC, Charron E, Weiss WA, Smirnov IV, Song JS, Olshen AB, Cha S, Zhao Y, Moore RA, Mungall AJ, Jones SJM, Hirst M, Marra MA, Saito N, Aburatani H, Mukasa A, Berger MS, Chang SM, Taylor BS, Costello JF. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science. 2014 Jan 10;343(6167):189-193. doi: 10.1126/science.1239947. Epub 2013 Dec 12. PubMed PMID: 24336570; PubMed Central PMCID: PMC3998672.

  3. Hyman DM, Smyth LM, Donoghue MTA, Westin SN, Bedard PL, Dean EJ, Bando H, El-Khoueiry AB, Pérez-Fidalgo JA, Mita A, Schellens JHM, Chang MT, Reichel JB, Bouvier N, Selcuklu SD, Soumerai TE, Torrisi J, Erinjeri JP, Ambrose H, Barrett JC, Dougherty B, Foxley A, Lindemann JPO, McEwen R, Pass M, Schiavon G, Berger MF, Chandarlapaty S, Solit DB, Banerji U, Baselga J, Taylor BS. AKT Inhibition in Solid Tumors With AKT1 Mutations. J Clin Oncol. 2017 Jul 10;35(20):2251-2259. doi: 10.1200/JCO.2017.73.0143. Epub 2017 May 10. PubMed PMID: 28489509; PubMed Central PMCID: PMC5501365.

  4. Chang MT, Asthana S, Gao SP, Lee BH, Chapman JS, Kandoth C, Gao J, Socci ND, Solit DB, Olshen AB, Schultz N, Taylor BS. Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. Nat Biotechnol. 2016 Feb;34(2):155-63. doi: 10.1038/nbt.3391. Epub 2015 Nov 30. PubMed PMID: 26619011; PubMed Central PMCID: PMC4744099.

  5. Chang MT, Bhattarai TS, Schram AM, Bielski CM, Donoghue MTA, Jonsson P, Chakravarty D, Phillips S, Kandoth C, Penson A, Gorelick A, Shamu T, Patel S, Harris C, Gao J, Sumer SO, Kundra R, Razavi P, Li BT, Reales DN, Socci ND, Jayakumaran G, Zehir A, Benayed R, Arcila ME, Chandarlapaty S, Ladanyi M, Schultz N, Baselga J, Berger MF, Rosen N, Solit DB, Hyman DM, Taylor BS. Accelerating Discovery of Functional Mutant Alleles in Cancer. Cancer Discov. 2017 Dec 15. doi: 10.1158/2159-8290.CD-17-0321. [Epub ahead of print] PubMed PMID: 29247016.

Visit PubMed for a full listing of Barry S. Taylor’s journal articles

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