Dr. Taylor is an Assistant Member in the Human Oncology and Pathogenesis Program, Assistant Attending Computational Oncologist in the Department of Epidemiology and Biostatistics, and Associate Director of the Marie-Josée and Henry R. Kravis Center for Molecular Oncology. The goal of his laboratory research is to define the germline and somatic abnormalities that mediate the genesis, progression, and response to therapy of human cancers. His research program lies at the interface of computational and cancer biology, employing translational genomic and functional genetic approaches to identify tumor cell-specific vulnerabilities that can be therapeutically exploited in diverse malignancies. Dr. Taylor’s lab has been involved in many collaborative studies exploring the genomic basic of diverse human cancer types and the development of computational methodologies for cancer genome discovery. His current research centers on exploring the molecular and evolutionary origins of response and resistance to cancer therapy, and defining the mechanisms, serial genetic evolution, and both biological and therapeutic significance of common and rare driver mutations in tumorigenesis. The lab’s overall goal is to capitalize on population-scale and data-driven approaches to accelerate clinical translation in molecularly defined populations of cancer patients.