Dr. Papaemmanuil is an Assistant Attending Computational Oncologist in the Department of Epidemiology and Biostatistics and an Affiliate Member of the Cancer Genetics and Biology Programme. She is affiliated with the Marie-Josée and Henry R. Kravis Center for Molecular Oncology, and is the Associate Director for the Center of Hematological Malignancies. Dr. Papaemmanuil was trained in Human Molecular Genetics at the University of Glasgow, and completed PhD studies in Population Genetics and Epidemiology and conducted her postdoctoral research at the Cancer Genome Project at the Wellcome Trust Sanger Institute in Cambridge UK. Dr Papaemmanuil is a certified computer systems and operations development analyst by the British Society of Computing. Dr Papaemmanuil’s research is focused on developing comprehensive laboratory and novel analytical methodologies to study the role of acquired mutations in cancer, and how these define clinical phenotype and determine therapeutic response. Dr Papaemmanuil works with large and well-annotated clinical trial cohorts to study the diagnostic, prognostic and predictive value of genomic variation and how this knowledge can guide development of future clinical protocols. To this effect she is leading a number of international multi-center consortia including the prospective molecular characterization for the International Working Group in myelo-displastic syndromes, the pan-myeloid meta-analysis, and genome profiling of the UK acute lymphocytic leukemia clinical trials. At MSK Dr Papaemmanuil leads integrative wholegenome, transcriptome and methylation studies of spatially and temporally separated samples in pediatric tumours. These studies are focused in understanding the genomic and clonal structure of pediatric genomes at diagnosis, and how these change during therapy and importantly disease progression. Informed by genomic findings, Dr Papaemmanuil uses primary patient tissues to study the biological consequences of disease defining mutations in cancer using single cell and iPSC cell lies. Dr Papaemmanuil is a European Society of Hematology Fellow, an American Society for Hematology Scholar, and a Josie Robertson Investigator.