Howard Tzvi Thaler, PhD

Associate Attending Biostatistician

Howard Tzvi Thaler, PhD

Associate Attending Biostatistician

Office Phone



Current Research Interests

Dr. Thaler’s current research interests center on data analytic paradigms that utilize data transformations and dimension-reduction techniques to obtain parsimonious and informative statistical models. He applies the strategies to analyze clinical and laboratory data, as well as to investigate properties of new statistical methods by Monte Carlo simulation. He continues to expand collaboration with the Strategic Planning, Quality Assurance and Quality of Care Initiative Groups of Hospital Administration to explore information retrieved from the MSKCC Institutional Data Base (IDB), with the goal of developing metrics and statistical models of trends in demographic, clinical and geographic profiles of patients undergoing several modalities of active treatment throughout the MSKCC health care system. This work includes studies such as comparative effectiveness, risk factors for hospital re-admission or surgical complications, and clinical outcome benchmarks in patient subpopulations. He has continued to work on the following applications: clinical and cognitive outcomes and statistical characterization of sequential measurements of tumor markers in ovarian cancer patients; outcomes research pertaining to critical care medicine; cardiac and pulmonary complications among surgical patients; and clinical and laboratory studies using various medical imaging techniques, including PET scanning, MR spectroscopy, dynamic contrast enhanced MRI, and bioluminescent imaging. He has also revisited a prior interest in studies conducted by the Palliative Medicine Service.


SUNY Buffalo


Dupont J, Tanwar MK, Thaler HT, Fleisher M, Kauff N, Hensley ML, Sabbatini P, Anderson S, Aghajanian C, Holland EC, Spriggs DR. Early Detection and Prognosis of Ovarian Cancer Using Serum YKL-40. Journal of Clinical Oncology 2004;22:3330-3339.

Chang VT, Hwang SS, Thaler HT, Kasimis B, Portenoy RK. The Memorial symptom assessment scale. Expert Review of Pharmacoeconomics and Outcomes Research 2004;4:171-178.

Moore KH, Thaler HT, Tan LK, Borgen PI, Cody III, HS. Immunohistochemically detected tumor cells in the sentinel lymph nodes of patients with breast carcinoma. Biologic metastasis or procedural artifact? Cancer 2004;100:929-934.

Patel MI, Subbaramaiah K, Du B, Chang M, Yang P, Newman RA, Cordon-Cardo C, Thaler HT, Dannenberg AJ. Celecoxib inhibits prostate cancer growth. Evidence of a COX-2 independent mechanism. Clinical Cancer Research (in press).

Temple LKF, Bacik J, Savatta S, Gottesman L, Paty P, Weiser M, Guillem J, Minsky BD, Kalman M, Thaler HT, Schrag D, Wong WD. The development of a validated instrument to evaluate bowel function after sphincter preserving surgery for rectal cancer. Dis Colon Rectum (in press)

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  1. Parducci A, Thaler H, Anderson. Stimulus averaging and the context for judgment. Percep and Psychophys 1968; 3(2B).

  2. Thaler H. Non‑parametric probability density estimation and the empirical characteristic function. State University of New York at Buffalo. Statistical Science Division 1974;Tech Rep No. 14.

  3. Wanebo HJ, Hansen J, Rosen P, Thaler H, Robbins G, Urban J, Oettgen H. Immunologic reactivity in patients with operable breast cancer. Neoplasm Immunity Mechanisms, Proceedings of a Chicago Symposium 1976; 167‑183.

  4. Wachtel SS, Koo GC, Breg WR, Thaler HT, Dillard GM, Rosenthal IM, Dosik H, Gerald PS, Saenger P, New M, Lieber E, Miller OJ. Serologic detection of a Y‑lined gene in XX males and XX true hermaphrodites. N Eng J Med 1976; 295:750‑754.

  5. Wanebo HJ, Rosen PP, Thaler T, Urban JA, Oettgen HF. Immunobiology of operable breast cancer. An assessment of biologic risk by immunoparameters. Ann Surg 1976; 184:258‑267.

  6. Yamazaki K, Boyse EA, Mike V, Thaler HT, Mathieson BJ, Abbott J, Boyse J, Zayas ZA, Thomas L Control of mating preferences in mice by genes in the major histocompatibility complex. J Exp Med 1976; 144:1324‑1335.

  7. Ridolfi RL, Rosen PP, Thaler H. Nevus cell aggregates associated with lymph nodes. Estimated frequency and clinical significance. Cancer 1977; 39:164‑171.

  8. Rosen PP, Ashikari R, Thaler H, Ishikawa S, Hirota T, Abe O, Yamamoto H, Beattie EJ Jr, Urban JA, Mike V. A Narrative study of some pathologic features of mammary carcinoma in Tokyo, Japan and New York, U.S.A. Cancer 1977; 39:429‑434.

  9. Nime FA, Rosen PP, Thaler HT, Ashikari R, Urban JA. Prognostic significance of tumor emboli in intramammary lymphatics in patients with mammary carcinoma. Am J Surg Pathol 1977; 1: 25‑30.

  10. Schmidt M, Deschner EE, Thaler HT, Clements L, Good RA. Gastrointestinal cancer studies in the heterotransplant system. Gastroenterol 1977; 72:829‑837.

  11. Wachtel SS, Thaler HT, Boyse EA. A second system of alloantigens expressed selectively in epidermal cells of the mouse. Immunogenetics 1977; 5:17‑23.

  12. Wanebo HJ, Thaler HT, Hansen JA, Rosen PP, Robbins GF, Urban JA, Oettgen HF, Good RA. Immunologic reactivity in patients with primary operable breast cancer. Cancer 1978; 41, No. 1:84‑94.

  13. Allen JD, Thaler HT, Deck MDF, Rottenberg DA. Leukoencephalopathy following high dose intravenous methotrexate chemotherapy. Quantitative assessment of white matter attenuation using computed tomography. Neuroradiology 1978; 16:44‑47.

  14. Thaler HT, Ferber PW, Rottenberg DA. A statistical method for determining the proportions of gray matter, white matter and CSF using computed tomography. Neuroradiology 1978; 16:133‑135.

  15. Thaler HT, Rottenberg DA, Pentlow K, Allen JC. A method for correcting for linear drift in CT brain scans. J Comput Assist Tomogr 1979; 3:251‑255.

  16. Mastrovito RC, Deguire KS, Clarkin J, Thaler H, Lewis JL Jr, Cooper E. Personality characteristics of women with gynecological cancer. Cancer Detect Prev 1979; 2(2): 281‑287.

  17. Mayer K, Chin B, Magnes J, Thaler HT, Lotspeich C, Baisley, A. Automated platelet counters. A comparative evaluation of latest instrumentation. Am J Clin Pathol 1980; 74:17‑32.

  18. Haghbin M, Murphy ML, Tan C, Clarkson BD, Thaler HT, Passe S, Burchenal J. A long‑term clinical follow‑up of children with acute lymphoblastic leukemia treated with intensive chemotherapy regimens. Cancer 1980; 46:241‑252.

  19. Galicich JH, Sundaresan N, Thaler HT. Surgical treatment of single brain metastases. Evaluation of results by CT scanning. J Neurosurg 1980; 53:63‑67.

  20. Thaler HT, Lu HC. Rottenberg DA. A method for locating homogeneous regions within CT brain slices. Am J Neuroradiol 1980; 1:475‑476.

  21. Voorhies RM, Sundaresan N, Thaler HT. The single supratentorial lesion. An evaluation of preoperative diagnostic tests. J Neurosurg 1980; 53:364‑368.

  22. Mertelsmann R, Thaler HT, To L, Gee TS, Mckenzie S, Schauer P, Friedman A, Arlin Z, Cirrincione C, Clarkson B. Morphological classification, response to therapy and survival in 263 adult patients with acute non‑lymphoblastic leukemia. Blood 1980; 56:773‑781.

  23. Haghbin M, Cunningham‑Rundles S, Thaler HT, Gupta S, Heckt S, Murphy Ml, Oettgen HF. Immunotherapy with oral BCG and serial immune evaluation in childhood lymphoblastic leukemia following 3 years of chemotherapy. Cancer 1980; 46:2577‑2586.

  24. Schulof RS, Bockman RS, Garofalo JA, Cirrincione C, Cunningham‑Rundles S, Fernandes G, Day NK, Pinsky CM, Incefy GS, Thaler HT Clarkson BD, Lee BJ, Good Ra, Gupta S. Multivariate analysis of T‑Cell functional defects and circulating serum factors in Hodgkin’s Disease. Cancer 1981; 48:964‑973.

  25. Friedman A, Schauer P, Mertelsmann R, Cirrincione C, Thaler HT, Dufour P, Teitelbaum H, Kempin S, Gee T, Arlin Z, Clarkson B. The significance of splenomegaly in 101 adults with acute lymphoblastic leukemia (ALL) at presentation and during remission. Blood 1981; 57:798‑801.

  26. Moody CE, Innes JB, Staiano‑Coico L, Incefy GS, Thaler HT, Weksler ME. Lymphocyte transformation induced by autologous cells XI. The effect of age on the autologous mixed lymphocyte reaction. Immunology 1981; 44:431‑438.

  27. Wallis LA, Gilder H, Thaler HT. Advancement of men and women in medical academia. A pilot study. J Amer Med Assoc 1981; 246:2350‑2353.

  28. Mertelsmann R, Drapkin RL, Gee TS, Kempin S, Passe S, Thaler HT, Arlin Z, Dowling M, Dufour P, Mckenzie S, To L, Comacho E, Oettgen HG, Burchenal JH, Clarkson B. Treatment of acute non‑lymphocytic leukemia in adults: Response to 2,2‑Anhydro‑1B‑D‑ Arabinofuranosyl‑5‑Fluorocytosine and Thioguanine on the L‑12 Protocol. Cancer 1981; 48:2136‑2142.

  29. Koziner B, Little C, Passe S, Thaler HT, Sklaroff R, Lee BJ, Clarkson B. Treatment of advanced diffuse histiocytic lymphoma: An analysis of prognostic variables. Cancer 1982; 49:1571‑1579.

  30. Pinsky CM, Wanebo HJ, Hilal EY, Strong EW, Thaler HT, Oettgen HF. Randomized trial of Levamisole in patients with squamous cell carcinoma of the head and neck: Preliminary results. In Immunoth Hum Cancer 1982; (Terry, D. and Rosenberg, S.A., eds.), Excerpta Medica, NY, pp. 353‑359.

  31. Hinkle LE, Thaler HT. The clinical classification of cardiac deaths. Circulation 1982; 65:457‑464.

  32. Kempin S, Lee BJ , Thaler HT, Koziner B, Hecht S, Gee Arlin ZA, Little C, Straus D, Reich L, Phillips E, Almondhiry H, Dowling M, Mayer K, Clarkson B. Combination chemotherapy of advanced chronic lymphocytic leukemia. The M‑2 Protocol (Vincristine, BCNU, Cyclophosphamide, Melphalan, and Prednisone). Blood 1982; 60:110‑1121.

  33. Thaler HT, Baglivo JA, Lu HC, Rottenberg DA. Repeated least squares analysis of simulated xenon CT measurements of regional cerebral blood flow. J Cereb Blood Flow Metab 1982; 2:408‑414.

  34. Karmali RA, Thaler HT, Cohen LA. Prostaglandin concentrations and prostaglandin synthetase activity in N‑nitrosomethylurea‑induced rat mammary adenocarcinoma. Eur J Cancer Clin Oncol 1983; 19:817.

  35. Karmali RA, Welt S, Thaler HT, Lefevre F. Prostaglandins in breast cancer: Relationship to disease stage and hormone status. Br J Cancer 1983; 48:689‑696.

  36. Lu L, Broxmeyer HE, Meyers PA, Moore MAS, Thaler HT. Association of cell cycle expression of Ia‑like antigenic determinants on normal human multipotential (CFU‑GEMM) and erythroid (BFU‑E) progenitor cells with regulation in vitro by acidic isoferitins. Blood 1983; 61:250‑256.

  37. Schauer P, Arlin ZA, Mertelsmann R, Cirrincione C, Friedman A, Gee TS, Dowling M, Kempin S, Straus DJ, Koziner B, Mckenzie S, Thaler HT, Dufour P, Little C, Dellaquila C, Ellis S, Clarkson B. Treatment of acute lymphoblastic leukemia in adults: Results of the L‑10 and L‑10M protocols. J Clin Oncol 1983; 1:462‑470.

  38. Straus DJ, Filippa DA, Lieberman PH, Koziner B, Thaler HT, Clarkson B. The non‑Hodgkin’s lymphomas: A retrospective clinical and pathologic analysis of 499 cases diagnosed between 1958 and 1969. Cancer 1983; 51:101‑109.

  39. Strife A, Lambek C, Wisniewski D, Arlin Z, Thaler H, Clarkson B. Proliferative potential of subpopulations of granulocyte‑macrophage progenitor cells in normal subjects and chronic myelogenous leukemia patients. Blood 1983; 62:389‑397.

  40. Aiken R, Leavengood JM, Kim J‑H, Deck MDF, Thaler HT, Posner JB. Metronidazole in the treatment of metastatic brain tumors. J Neurooncol 1984; 2:105‑111.

  41. Al‑Katib A, Koziner B, Kurland E, Little C, Labriola D, Thaler HT, Straus DJ, Lee BJ, Clarkson BD. Treatment of diffuse poorly differentiated lymphocytic lymphoma (DPDL): An analysis of prognostic variables. Cancer 1984; 53:2404‑2412.

  42. Dhawan V, Haughton VM, Thaler HT, Lu H‑C, Rottenberg DA. Accuracy of stable xenon‑CT measurements of regional cerebral blood flow: Effect of extrapolated estimates of brain‑blood partition coefficients. J Comput Assist Tomogr 1984; 8:208‑212.

  43. Karmali RA, Wustrow T, Thaler HT, Good RA. Prostaglandins in cells of the lymphoid system in AKR leukemia. Cancer Res 1984; 44:467‑471.

  44. Koziner B, Sklaroff RB, Labriola D, Thaler HT, Straus DJ, Young CW, Nisce L, Oettgen HF, Lee BJ, Clarkson BD. Six drug combination chemotherapy for non‑Hodgkin’s lymphoma. Cancer 1984; 53:2592‑2600.

  45. Mark DA, Alonso DR, Quimby F, Thaler HT, Kim YT, Fernandes G, Good RA, Weksler ME. Effects of nutrition on disease and life span. I. Immune responses, cardiovascular pathology, and life span in MRL mice. Am J Pathol 1984; 117:125‑130.

  46. Mark DA, Alonso DR, Tack‑Goldman K, Thaler HT, Tremoli E, Weksler BB, Weksler ME. Effects of nutrition on disease and life span. II. Vascular disease, serum cholesterol, serum thromboxane, and heart‑produced prostacyclin in MRL mice. Am J Pathol 1984; 117:125‑130.

  47. Obbens Eat, Kim J‑H, Thaler HT, Deck MDF, Posner JB. Metronidazole as a radiation enhancer in the treatment of metastatic epidural spinal cord compression. J Neurooncol 1984; 2:99‑104.

  48. Thaler HT. Nonparametric estimation of the hazard ratio. J Amer Stat Assoc 1984; 79:290‑293.

  49. Thaler HT, Braun HI. On the apparent clustering of clonal albumin production and enzyme levels. Biometrics 1984; 40:1095‑1102.

  50. Thaler HT. Comment on “A statistical model for positron emission tomography”. J Amer Stat Assoc 1985; 80:33.

  51. Dutkowski RT, Lesh R, Staiano‑Coico L, Thaler T, Darlington GJ, Weksler ME. Increased chromosomal instability in lymphocytes from elderly humans. Mutat Res 1985; 149:505‑512.

  52. Junck L, Dhawan V, Thaler HT, Rottenberg DA. Effects of xenon and krypton on regional cerebral blood flow in the rat. J Cereb Blood Flow Metab 1985; 5:126‑132.

  53. Gebhard DF, Jr, Mittelman A, Cirrincione C, Thaler HT, Koziner B: Comparative analysis of surface membrane immunoglobulin determination by flow cytometry and fluorescence microscopy. J Histocompat Cytochem 1986; 34:475‑481.

  54. Andreeff M, Hansen H, Cirrincione C, Fillipa D, Thaler H. Prognostic value of DNA/RNA flow cytometry of B‑cell non‑Hodgkins lymphoma: Development of laboratory model and correlation with four taxonomic systems. In Clinical Cytometry 1986; (Andreeff, M., ed.) Volume 468. New York Academy of Sciences, New York, pp. 368‑386.

  55. Lieberman PH, Filippa DA, Straus DJ, Thaler HT, Cirrincione C, Clarkson BD. An evaluation of malignant lymphomas using three classifications and the working formulation based on 482 cases with a median follow‑up of 11.9 years. Am J Med 1986; 81:365‑380.

  56. Patchell RA, Cirrincione C, Thaler HT, Galicich JH, Posner JB. Surgery plus radiation versus radiation alone in the treatment of single brain metastases. Neurology 1986; 36:447‑453.

  57. Phillips PC, Thaler HT, Berger CA, Fleisher M, Wellner D, Rottenberg DA. Acute high‑dose methotrexate neurotoxicity in the rat. Ann Neurol 1986; 20:583‑589.

  58. Delattre JY, Krol G, Thaler HT, Shapiro WR, Posner JB. Distribution of brain metastases. Arch Neurol 1988; 45:741-744.

  59. Fadul C, Wood J, Thaler HT, Galicich J, Patterson RH, Posner JB. Morbidity and mortality of craniotomy for excision of supratanetorial gliomas. Ann Neurol 1988; 38:1374-1379.

  60. Hinkle LE, Jr, Thaler HT, Merke DP, Renier‑Berg D, Morton NE. The risk factors for arrhythmic death in a sample of men followed for 20 years. Am J Epidemiol 1988; 127:500-515.

  61. Fadul CE, Lemann W, Thaler HT, Posner JB. Perforation of the gastrointestinal tract in patients receiving steroids for neurological disease. Neurology 1988; 38:348-352.

  62. Recht L, Straus DJ, Cirrincione C, Thaler HT, Posner JB. Central nervous system metastases from non‑Hodgkin’s lymphoma (CNSL): treatment and prophylaxis. Am J Med 1988; 84:425-435.

  63. Feldmann E, Gandy SE, Becker R, Zimmerman R, Thaler HT, Posner JB, Plum F. MRI demonstrates descending transtentorial herniation. Neurology 1988; 38:697-701.

  64. Delattre JY, Arbit E, Thaler HT, Lau N, Galicich JH, Posner JB. High dose versus low dose dexamethasone in experimental epidural spinal cord compression. J Neurosurg 1988; 22:1005-1007.

  65. Toth M, Witkin SS, Ledger W, Thaler HT. The role of infection in the etiology of preterm birth. Obstet Gynecol 1988; 71:723-726.

  66. Tross S, Price RW, Navia B, Thaler HT, Gold J, Hirsch DA, Sidtis J. Neuropsychological characterization of the AIDS dementia complex: A preliminary report. AIDS 1988; 2:81-88.

  67. Blass JP, Gleason P, Brush D, Diponte P, Thaler HT. Thyamine and Alzheimer’s disease: A pilot study. Arch Neurol 1988; 45:833-835.

  68. Delattre JY, Rosenblum MK, Thaler HT, Mandell L, Shapiro WR, Posner JB. A model of radiation myelopathy in the rat: pathology, regional capillary permeability changes and treatment with dexamethasone. Brain 1988; 111:1319-1336.

  69. Hiesiger EM, Picco-Del Bo A, Lipschutz LE, Basler GA, Thaler HT, Posner JB, Shapiro WR, Cotzias GC. Experimental meningeal carcinomatosis selectively depresses local cerebral glucose utilization in rat brain. Neurology 1989; 38:90-95.

  70. Krauss AN, Fatica N, Lewis BS, Cooper R, Thaler HT, Cirrincione C, O’loughlin J, Levin A, Engle MA, Auld Pam. Pulmonary function in preterm infants following treatment with intravenous indomethacin. Am J Dis Child 1989; 143:78-81

  71. Delattre JY, Arbit E, Thaler HT, Rosenblum MK, Posner JB. A dose-response study of dexamethasone in a model of spinal cord compression caused by epidural tumor. J Neurosurg 1989; 70:920-925.

  72. Portenoy RK, Galer B, Salamon O, Frelich M, Finkel JE, Milstein D, Thaler HT, Berger M, Lipton R. Identification of Epidural Neoplasm: Radiography and Bone Scintigraphy in the Symptomatic and Asymptomatic Spine. Cancer 1989; 64:2207-2213.

  73. Phillips PC, Thaler HT, Allen JC, Rottenberg DA. Leucovorin reverses acute high-dose methotrexate neurotoxicity in the rat. Ann of Neurol 1989; 25:365-372.

  74. Deangelis LM, Mandell LR, Thaler HT, Kimmel DW, Galicich JH, Fuks Z, Posner JB. The role of post-operative radiotherapy after resection of single brain metastases. J Neurosurg 1989; 24:798-805.

  75. Dhawan V, Poltorak A, Moeller JR, Jarden JO, Strother SC, Thaler H, Rottenberg A. Positron emission tomographic measurement of blood-to-brain and blood-to-tumor transport of 82RbI: Error analysis and computer simulations. Phys Med Bio 1989; 34: 1173-1784.

  76. Jennings MT, Ebrahim SAD, Thaler HT, Jenning FDL, Asadourian LLH, Shapiro Jr. Immunophenotypic difference between normalglia, astrocytomas and malignant gliomas: correlation with karyotype, natural history and survival. J Neuroimmunol 1989; 25:7-28.

  77. Hagen N, Cirrincione C, Thaler HT, Deangelis L. The role of whole brain radiation therapy following resection of cerebral metastasis from melanoma. Neurology 1990; 40:158-160.

  78. Deangelis L, Yahalom J, Heinemann MH, Cirrincione C, Thaler HT, Krol G. Primary central nervous system lymphoma: Combined treatment with chemotherapy and radiotherapy. Neurology 1990; 40:80-86.

  79. Kent M, Wachtel S, Thaler HT. Direct estimation of serological H-Y antigen by flow cytometry. Hum Genet 1990; 85:127-129.

  80. Ko L, Sheu K-Fr, Young O, Thaler HT, Blass IP. Expression in cultured neuroblastoma cells of epitopes associated with affected neurons in Alzheimer’s disease. Am J Pathol 1990; 136:807-819.

  81. Shlegel U, Moots PL, Rosenblum MK, Thaler HT, Furneaux HM. Expression of Transforming Growth Factor Alpha in Human Gliomas. Oncogene 1990; 5: 1839-1842.

  82. Jennings MT, Asadourian LLH, Jennings VDL, Shapiro JR, Thaler HT. Factor analysis of the immunophenotypes of astrocytomas and malignant gliomas: correlations with tumor grade and patient survival. J Neurooncology 1990; 9:265-273.

  83. Thaler HT, Friedlander-Klar H, Portenoy RK, Houde RW. Statistical analysis of a large database of analgesic clinical trials. American Statistical Assoc. Proceedings of the Biopharmaceutical Section 1990; pp. 113-117.

  84. Cohen AM, Tremiterra S, Candela F, Thaler H, Enker WE, Sigurdson ER, Quan S. Prognosis of node-positive colon cancer. Cancer 1991; 67:1859-1861.

  85. Portenoy RK, Khan E, Layman M, Lapin J, Malkin MG, Foley KM, Thaler HT, Cerbone DJ, Inturrisi C. Chronic morphine therapy for cancer pain: plasma and cerebrospinal fluid morphine and morphine-6-glucuronide concentrations. Neurology 1991; 41:1457-1461.

  86. Thaler HT, Friedlander-Klar H, Cirrincione C, Portenoy RK, Wallenstein Sl, Foley KM, Houde RW. A statistical approach to measuring analgesic response. In Bond M, Charlton JE, Woolf CJ (eds). Proceedings of the VIth World Congress on Pain Elsevier Science Publishers BV. 1991; pp. 539-542.

  87. Huang H-M, Toral-Barza L, Thaler H, Tofel-Grehl B, Gibson GE. Inositol phosphates and intracellular calcium after bradykinin stimulation in fibroblasts from young, normal aged and Alzheimer donors. Immunobiology of Aging 1991; 12:201-203.

  88. Miller E, Quan S, Thaler HT. Treatment of squamous carcinoma of the anal canal. Cancer 1991; 67:2038.

  89. Yiengpruksawan A, Coit DG, Thaler H, Urmacher C, Knapper WK. Merkel Cell Carcinoma: prognosis and management. Arch Surg 1991; 126:1514-1519.

  90. Spiro RH, Thaler HT, Hicks WF, Kher UA, Huvos AH, Strong EW. The importance of clinical staging of minor salivary gland carcinoma. Am J Surg 1991; 162:330-336.

  91. Armstrong J, Harrison LB, Thaler HT, Friedlander-Klar H, Fass DE, Zelefsky MJ, Shah JP, Strong EW, Spiro RH. The indicators for elective treatment of the neck in cancer of the major salivary glands. Cancer 1992; 69:615-619.

  92. Deangelis LM, Yahalom J, Thaler HT, Kher U. Combined modality therapy for primary central nervous system lymphoma. J Clin Oncol 1992; 10:635-643.

  93. Portenoy RK, Thaler HT, Inturrisi CE, Friedlander-Klar H, Foley KM. The metabolite, morphine-6-glucuronide, contributes to the analgesia produced by morphine infusion in pain patients with normal renal function. Clin Pharmacol Ther 1992; 51:422-431.

  94. Jaehne J, Urmacher C, Thaler HT, Friedlander-Klar H, Cordon-Cardo, C And Meyer H.J. Expression of Her/2 oncogene product p185 in correlating to cliniopathological and prognostic factors of gastric carcinoma. J Clin Res Clin Oncol 1992; 118:474-479.

  95. Wachtel MS, Thaler HT, Gangi MD, Hajdu SI. Immunoperoxidase staining of cervico-vaginal smears after radiation therapy. Acta Cytologica 1992; 36:305-309.

  96. Thaler HT, Friedlander-Klar H, Portenoy RK, Inturrisi CE, Foley KM. Pharmacodynamics of analgesia produced by morphine and morphine-6-glucuronide, its active metabolite. Proceedings of Biopharmaceutics Section of the American Statistics Association, 1992.

  97. Portenoy RK, Miransky J, Thaler HT, Hornung J, Bianchi C, Cibas-Kong I, Feldhamer E, Lewis F, Matamoros I, Sugar MZ, Olivieri AP, Kemeny NE, Foley KM. Pain in ambulatory patients with lung or colon cancer prevalence, characteristics and impact. Cancer 1992; 70:1616-1624.

  98. Laquaglia MP, Lucas A, Thaler HT, Friedlander-Klar H, Exelby PR, Groeger JS. A prospective analysis of vascular access device-related infections in children. J Ped Surg 1992; 27:840-842.

  99. Petrek JA, Peters MM, Cirrincione C, Thaler HT. A prospective randomized trial of single versus multiple drains in the axilla after lymphadenectomy. Surg Gynecol Obstetr 1992; 175:405-409.

  100. Black RS, Barclay LL, Nolan KA, Thaler HT, Hardiman ST, Blass JP. Pentoxifylline in cerebrovascular dementia. J Amer Geri Soc 1992; 40:237-44.

  101. Liberman L, Dershaw DD, Deutch BM, Thaler HT, Lippin BS. Screening mammography: value in women 35-39 years old. Am J Roentgenol 1993; 16153-56.

  102. Herman LL, Kurtz RC, Mckee KJ, Sun M, Thaler HT, Winawer SJ. Risks factors associated with vasovagal reactions during colonoscopy. Gastrointest Endosc 1993; 39:388-391.

  103. Fortner JG, Lauwers GY, Thaler HT, Concepcion R, Friedlander-Klar H, Kher U, Maclean BJ. Nativity, complications, pathology are determinants of surgical results for gastric cancer. Cancer 1994; 73:8-14.

  104. Groeger JS, Lucas AB, Thaler HT, Friedlander-Klar H, Brown Ae, Kiehn TE, Armstrong D. Infectious morbidity associated with chronic venous access devices in cancer patients. Ann Int Med 1993; 119:1168-1174.

  105. Kurita A, Blass JP, Nolan KA, Black RS, Thaler HT. Relation between cognitive status and Behavioral Impairment in Alzheimer’s Disease and mixed dementia. J Amer Geriatr Soc 1993; 41:732-736.

  106. Cherny NI, Thaler HT, Friedlander-Klar H, Lapin J, Foley KM, Houde R, Portenoy RK. Opioid responsiveness of cancer pain syndromes caused by neuropathic or nociceptive mechanisms: A combined analysis of controlled single dose studies. Neurology 1994; 44:857-861.

  107. Portenoy RK, Thaler HT, Kornblith AB, Mccarthy Lepore J, Friedlander-Klar H, Kiyasu E, Sobel K, Coyle N, Kemeny N, Norton L, Scher H. The Memorial Symptom Assessment Scale: An instrument for the evaluation of symptom prevalence, characteristics, and distress. Eur J Cancer 1994; 30A(9):1326-1336.

  108. Portenoy RK, Thaler HT, Kornblith AB, Lepore JM, Friedlander-Klar H, Kiyasu E, Sobel K, Coyle N, Smart-Curly T, Koslovsky S, Kemeny N, Norton L, Hoskins W, Scher H. Symptom prevalence, characteristics and distress in a cancer population. Quality Life Res 1994; 3:183-189.

  109. Mahmood U, Alfieri AA, Thaler H, Cowburn D, Koutcher JA: Radiation dose-dependent changes in tumor metabolism measured by 31nuclear magnetic resonance spectroscopy. Cancer Res 1994; 54:4885-4891.

  110. Kelsen D, Portenoy RK, Thaler HT, et al. Pain and depression in patients with newly diagnosed pancreas cancer. J Clin Oncol 1995; 13:748-755.

  111. Makar TK, Cooper AJL, Tofelgrehl B, Thaler HT, Blass JP. Carnitine, carnitine acetyltransferase, and glutathione in alzheimer brain. Neuro Res 1995; 20:705-711.

  112. Seidman AD, Portenoy R, Yao TJ, Lepore J, Mont EK, Kortmansky J, Onetto N, Ren L, Grechko J, Beltangady M, Usakewicz J, Souhrada M, Houston C, Mc Cabe M, Salvaggio R, Thaler H, Norton L . Quality of life in phase II trials: a study of methodology and predictive value in patients with advanced breast cancer treated with Paclitaxel plus Granulocyte colony-stimulating factor. J Natl Cancer Instit 1995; 87:1316-1322.

  113. Tiseo PJ, Thaler H, Lapin J, Inturrisi CE, Portenoy RK, Foley KM. Morphine-6-Glucuronide concentrations and opioid-related side effects: A survey in cancer patients. Pain 1995; 61:47-54.

  114. Barber GR, Miransky J, Brown AE, Coit DG, Lewis FM, Thaler HT, Kiehn TE, Armstrong D. Direct observations of surgical wound infections at a comprehensive cancer center. Arch Surg 1995; 130 (10):1042-1047.

  115. Enker WE, Thaler HT, Cranor Ml, Polyak T. Total mesorectal excision in the operative treatment of rectal cancer. J Amer Coll Surg 1995; 181 (4): 335-346.

  116. Kornblith AB, Thaler HT, Wong GY, Vlamis V, Lepore J, Loseth D, Hakes T, Hoskins WJ, Portenoy RK. Quality of life of women with ovarian cancer. Gynecol Oncol 1995; 59:231-242.

  117. Wang Y, Corr JG, Thaler HT, Tao Y, Fair WR, Heston WDW: Decreased growth of established human prostate LNCAP tumors in Nude-Mice fed a low-fat diet. J Natl Cancer Inst 1995; 87(19):1456-1462.

  118. Max MB, Donovan M, Miaskowski CA, Ward SE, Gordon D, Bookbinder M, Cleeland CS, Coyle N, Kiss M, Thaler H, Janjan N, Weinstein S, Edwards WT. Quality improvement guidelines for the treatment of acute pain and cancer pain. J Am Med Assoc 1995; 274:1874-1880.

  119. Jakubowski AA, Bajorin DF, Templeton MA, Chapman PB, Cody BY, Thaler H, Tao Y, Filippa DA, Williams L, Sherman Ml, Garnick MB, Houghton AN: Phase I study of continuous-infusion recombinant macrophage colony-stimulating factor in patients with metastatic melanoma. Clin Care Res 1996; 2:295-302.

  120. Perrotti M, Kaufman RP, Jennings TA, Thaler HT, Soloway SM, Rifkin MD, Fisher HAG (1996). Endo-rectal coil Magnetic-Resonance-Imaging in clinically localized prostate cancer: Is it accurate? J Urol 1996; 156:106-109.

  121. Breitbart W, Rosenfeld BD, Passik SD, Mc Donald MV, Thaler H, Porteony RK: The undertreatment of pain in ambulatory AIDS patients. Pain 1996; 65:243-249.

  122. Collins JJ, Geake J, Grier HE, Houck CS, Thaler HT, Weinstein HJ, Yeboaa Twum-Danso N, Berde CB. Patient-controlled analgesia for mucositis pain in children: A three period cross-over study comparing morphine and hydromorphone. Pediatrics 1996; 129:723-728.

  123. Bookbinder M, Coyle N, Kiss M, Goldstein Ml, Holritz K, Thaler H, Gianella A, Derby S, Brown M, Ho MN, Portenoy R.: Implementing national standards for cancer pain management: Program model and evaluation. J Pain Symptom Manage 1996; 12:334-347.

  124. Breitbart W, Mcdonald MV, Rosenfeld B, Passik D, Hewitt D, Thaler H, Portenoy RK. Pain in ambulatory AIDS patients. I: Pain characteristics and medical correlates. Pain 1996; 68:315-321.

  125. Rosenfeld B, Breitbart W, Mcdonald MV, Passik SD, Thaler H, Portenoy RK. Pain in ambulatory AIDS patients. II: Impact of pain on psychological functioning and quality of life. Pain 1996; 68:323-328.

  126. Harrison LB, Zelefsky MJ, Pfister DG, Carper E, Raben A, Kraus DH, Strong EW, Rao A, Thaler H, Polyak T, Portenoy R.: Detailed quality of life assessment in patients treated with primary radiation therapy for squamous cell cancer of the base of tongue. Head Neck 1997; 19:169-175.

  127. Batchelor TT, Taylor LP, Thaler HT, Posner JB, De Angelis LM. Steroid myopathy in cancer patients. Neurology 1997; 48:1234-1238.

  128. Enker WE, Havenga K, Polyak T, Thaler H, Cranor M. Abdominoperineal resection via total mesorectal excision and autonomic nerve preservation for low rectal-cancer. World J Surg 1997; 21:715-720.

  129. Pinto JT, Qiao CH, Xing J, Rivlin RS, Protomas. Ml, Weissler Ml, Tao Y, Thaler H, Heston WDW. Effects of garlic thioallyl derivatives on growth, glutathione concentration, and polyamine formation of human prostate carcinoma-cells in culture. Am J Clin N 1997; 66:398-405.

  130. Voltz RD, Albrich WC, Nagele A, Schumm F, Wick M, Freiburg A, Gautel M, Thaler HT, Aarli J, Kirchner T. Paraneoplastic myasthenia-gravis - detection of anti-MGT30 (Titin) antibodies predicts thymic epithelial tumor. Neurology 1997; 49:1454-1457.

  131. Koutcher JA, Alfieri AA, Thaler H, Matei C, Martin DS. Radiation enhancement by biochemical modulation and 5-fluorouracil. Int J Radiat Oncol 1997; 39:1145-1152.

  132. Goldman SA, Kirschenbaum B, Harrison-Restelli C, Thaler HT: Neuronal precursors of the adult rat subependymal zone persit into senescence, with no decline in spatial extent or response to BDNF. J Neurobiol 1997; 32:554-566.

  133. Kelsen DP, Portenoy R, Thalerh, Tao Y, Brennan M: Pain as a predictor of outcome in patients with operable pancreatic carcinoma. Surgery 1997; 122: 53-59.

  134. Sogani PC, Perrotti M, Herr HW, Fair WR, Thaler HT, Bosl G: Clinical stage I testis cancer - long-term outcome of patients on surveillance. J Urol 1998; 159:855-858.

  135. Chervenak FA, Skupski DW, Romero R, Myers LK, Smithlev. M, Rosenwaks Z, Thaler HT: How accurate is fetal biometry in the assessment of fetal age. Am J Obstet Gynecol 1998; 178:678-687.

  136. Chang VT, Thaler HT, Polyak TA, Kornblith AB, Lepore JM, Portenoy RK: Quality-of-life and survival: the role of multidimensional symptom assessment. Cancer 1998; 83:173-179.

  137. Landolfi JC, Thaler HT, Deangelis LR: Adult brain-stem gliomas. Neurology 1998; 51:1136-1139.

  138. Disa JJ, Hidalgo DA, Cordeiro PG, Winters RM, Thaler H: Evaluation of bone height in osseous free-flap mandible reconstruction - an indirect measure of bone mass. Plas Reconstr Surg 1999; 103:1371-1377.

  139. Sheu K-FR, Brown AM, Haroutunian V, Kristal BS, Thaler H, Lesser M, Kalaria RN, Relkin NR, Mohs RC, Lilius L, Lannfelt L, Blass JP. Modulation by DLST of the genetic risk of Alzheimer’s disease in a very elderly population. Ann Neurol 1999; 45:48-53.

  140. Vogl D, Rosenfeld B, Breitbart W, Thaler H, Passik S, Mcdonald M, Portenoy RK. Symptom prevalence, characteristics and distress in AIDS outpatients. J Pain Symptom Manage 1999;18:253-262.

  141. Mora J, Filippa DA, Thaler HT, Polyak T, Cranor ML, Wollner N. Large-cell non-hodgkin-lymphoma of childhood - analysis of 78 consecutive patients enrolled in 2 consecutive protocols at the Memorial Sloan Kettering Cancer Center. Cancer 2000;88:186-197.

  142. 142. Lee CT, Katz J, Shi WJ, Thaler HT, Reuter VE, Russo P. Surgical-management of renal tumors 4 cm. or less in a contemporary cohort. J Urol 2000;163:730-736.

  143. Smith AJ, Nissan A, Lanouette NM, Shi WJ, Guillem JG, Wong WD, Thaler H, Cohen AM. Prokinetic effect of erythromycin after colorectal surgery - randomized, placebo-controlled, double-blind study. Dis Col Rec 2000;43:333-337.

  144. Gu M, Shi W, Huang J, Barakat RR, Thaler HT, Saigo PE. Association between initial diagnostic procedure and hysteroscopy and abnormal peritoneal washings in patients with endometrial carcinoma. Cancer 2000; 90:143-147.

  145. Martin J, Robitaille D, Perrault LP, Pellerin M, Page P, Searle N, Cartier R, Hebert Y, Pelletier LC, Thaler HT. Reinfusion of mediastinal blood after heart surgery. J Thor Surg 2000;120:499-504.

  146. Baron RH, Kelvin JF, Bookbinder M, Cramer L, Borgen PI, Thaler HT. Patients sensations after breast-cancer surgery - a pilot study. Cancer Prac 2000;8:215-222.

  147. Gu M, Shi WJ, Barakat RR, Thaler HT, Saigo PE. Peritoneal washings in endometrial carcinoma - a study of 298 patients with histopathologic correlation. Act Cytol 2000;44:783-789.

  148. Karadimitris A, Manavala. JS. Thaler HT, Notaro R, Araten DJ, Nafa K, Roberts IAG, Weksler ME, Luzzatto L. Abnormal t-cell repertoire is consistent with immune process underlying the pathogenesis of paroxysmal-nocturnal hemoglobinuria. Blood 2000;96:2613-2620.

  149. Butler LM, Agus DB, Scher HI, Higgins B, Rose A, Cordon-Cardo C, Thaler HT, Rifkind RA, Marks PA, Richon VM. Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate-cancer cells in-vitro and in-vivo. Cancer Res 2000;60:5165-5170.

  150. Chang VT, Hwang SS, Feuerman M, Kasimis BS, Thaler HT. The Memorial symptom assessment scale short form (MSAS-SF) Cancer 2000;89:1162-1171.

  151. Collins JJ, Byrnes ME, Dunkel IJ, Lapin J, Nadel T, Thaler HT, Polyak T, Rapkin B, Portenoy RK. The measurement of symptoms in children with cancer. J Pain Symptom Manage 2000;19:363-377.

  152. Puig-La Calle J, Quayle J, Thaler HT, Shi W, Paty PB, Quan SH, Cohen AM, Guillem JG. Favorable short-term and long-term outcome after elective radical rectal cancer resection in patients 75 years of age or older. Dis Colon Rectum 2000;43:1704-1709.

  153. Xu S, Zakian K, Thaler H, Matei C, Alfieri A, Chen YC, Koutcher JA. Effects of motexafin gadolinium on tumor metabolism and radiation sensitivity. Int J Radiat Oncol 2001;49:1381-1390.

  154. Gu M, Shi W, Shi W, Barakat RR, Thaler HT, Saigo PE. Pap smears in patients with endometrial carcinoma. Acta Cytologica 2001;45:555-560.

  155. Dellit TH, Armaslou. B, Bosl GJ, Sepkowitz KA, Thaler H, Blaskovitz J. A method for assessing house staff workload as a function of length of stay (Letter). JAMA 2001;286:1023-1024.

  156. Miransky J, Ruo L, Nicoletti S, Eagan J, Sepkowitz K, Margetson N, Thaler H, Cohen AM, Guillem JG. Impact of a surgeon trained observer on accuracy of colorectal surgical site infection rates. Dis Colon Rectum 2001; 44:1100-1105.

  157. Bach AM, Hann LE, Hadar O, Shi W, Yoo H-H, Giess C, Sheinfeld J, Thaler H. Testicular microlithiasis: what is its association with testicular cancer? Radiology 2001;220:70-75.

  158. Miransky J, Ruo L, Eagan NS, Sepkowitz K, Margetson N, Thaler H, Cohen AM, Guillem JG. Impact of a surgeon-trained observer on accuracy of colorectal surgical site infection rates. Dis Colon Rectum 2001;44:1100-1105.

  159. Araten DJ, Swirsky D, Karadimitris A, Notaro R, Nafa K, Bessler M, Thaler HT, Castrp-Malaspina H, Childs BH, Boulad F, Weiss M, Anagnostopoulos N, Kutlar A, Savage DG, Maziarz RT, Jhanwar S, Luzzatto L. Cytogenetic and morphologic abnormalities in paroxysmal nocturnal haemoglobinuria. Br J Haematol 2001; 115: 360-368.

  160. Collins JJ, Devine TD, Dick GS, Johnson EA, Kilham HA, Pinkerton CR, Stevens MM, Thaler HT, Portenoy RK. The measurement of symptoms in young children with cancer - the validation of the Memorial symptom assessment scale in children aged 7-12. J Pain Symptom Manage 2002;23:10-16.

  161. Battleman DS, Callahan M, Thaler H. Rapid antibiotic delivery and appropriate antibiotic selection reduce length of stay in patients with community-acquired pneumonia: a link between quality of care and resource utilization. Arch Intern Med 2002;162:682-688.

  162. Ko LW, Sheu KFR, Thaler HT, Markesbery WR, Blass JP. Selective loss of KGDHC enriched neurons in Alzheimer temporal cortex - does mitochondrial variation contribute to selective vulnerability. J Mol Neuro 2002;17:361-369.

  163. Gollub MJ, Ginsberg MS, Cooper C, Thaler HT. Quality of virtual colonoscopy in patients who have undergone raditiona therapy or surgery - how successful are we? Am J Roentgenol 2002;178:1109-1116.

  164. Bach AM, Hann LE, Hadar O, Shi W, Yoo HH, Giess CS, Sheinfeld J, Thaler H. Testicular microlithiasis - respond (Letter). Radiology 2002;223:583-584.

  165. Khan RB, Shi W, Thaler HT, Deangelis LM, Abrey LE. Role of intrathecal methotrexate in the treatment of primary central nervous system lymphoma. J Neurooncology 2002;58:175-178.

  166. Temple L, Baron R, Cody HS, Fey J, Thaler H, Borgen PI, Heerdt AS, Montgomery L, Petrek JA, Van Zee KJ. Sensory morbidity after sentinel lymph node biopsy and axillary dissection: A prospective study of 233 women. Ann Surg Oncol 2002;9:654-662.

  167. Tjuvajev J, Doubrovin M, Akhurst T, Cai S, Balatoni J, Alauddin MM, Finn R, Beattie B, Thaler HT, Larson S, Conti P, Blasberg R. Comparison of Radiolabeled Nucleoside Probes (FIAU, FHBG and FHPG) for PET Imaging of HSV1-tk Gene Expression. J Nucl Med 2002;43:1072-1083.

  168. Howe LR, Subbaramaiah K, Patel J, Masferrer JL, Deora A, Hudis C, Thaler HT, Muller WJ, Du B, Brown AMC, Dannenberg AJ. Celecoxib a selective cyclooxygenase-2 inhibitor protects against HER-2/neu-induced breast cancer. Cancer Res 2002; 62:5405-5407.

  169. Aung L, Gorlick RG, Shi W, Thaler H, Shorter NA, Healey JH, Huvos AG, Meyers PA. Second malignant neoplasms in long-term survivors of osteosarcoma - Memorial Sloan Kettering Cancer Center experience. Cancer 2002;95:1728-1734.

  170. Gupta M, Thaler HT, Steinherz L. Presence of prolonged dispersion of QT intervals in late survivors of childhood anthracycline therapy. Pediatr Hematol Oncol 2002;19:533-542.

  171. Giess CS, Thaler H, Bach AM, Hann LE. Clinical experience with upper extremity venous ultrasound in a high-risk cancer population. J Ultrasound Med 2002;21:1365-1370.

  172. Kim YM, Chaiworapongsa T, Gomez R, Bujold E, Yoon BH, Rotmensch S, Thaler HT, Romero R. Failure of physiologic transformation of the spiral arteries in the placental bed in preterm premature rupture of membranes. Am J Obstet Gynecol 2002;187:1137-1142.

  173. Baron RH, Fey JV, Raboy S, Thaler HT, Borgen PI, Temple LK, VanZee KJ. Eighteen sensations after breast cancer surgery: a comparison of sentinel lymph node biopsy and axillary lymph node dissection. Oncol Nurs Forum 2002;29:651-659.

  174. Bach AM, Hann LE, Shi W, Giess CS, Yoo HH, Sheinfeld J, Thaler HT. Is there an increased incidence of contralateral testicular cancer in patients with intratesticular microlithiasis? Am J Roentgenol 2003;180:497-500.

  175. Teruya-Feldstein J, Donnelly GB, Goy A, Hegde A, Nanjangud G, Qin J, Thaler H, Gilles F, Dyomin VG, Lloyd KO, Zelenetz AD, Houldsworth J, Chaganti RS. MUC-1 mucin protein expression in b-cell lymphomas. Appl Immuno 2003;11:28-32.

  176. Aung L, Gorlick R, Healey JH, Shi W, Thaler HT, Shorter NA, Huvos AG, Meyers PA. Metachronous skeletal osteosarcoma in patients treated with adjuvant and neoadjuvant chemotherapy for nonmetastatic osteosarcoma. J Clin Oncol 2003;21:342-348.

  177. Dyke JP, Panicek DM, Healey JH, Meyers PA, Huvos AG, Schwartz LH, Thaler HT, Tofts PS, Gorlick R, Koutcher JA, Ballon D. Necrotic fraction estimation of osteogenic and Ewing sarcomas undergoing induction chemotherapy using dynamic enhanced MR imaging. Radiology 2003; 228:271-278.

  178. Nathanson DR, Espat NJ, Nash GM, D’Alessio M, Thaler H, Minsky BD, Enker W, Wong D, Guillem J, Cohen A, Paty PB. Evaluation of preoperative and postoperative radiotherapy on long-term functional results of straight coloanal anastomosis. Dis Colon Rectum 2003; 46:888-894.

  179. Kim YM, Bujold E, Chaiworapongsa T, Gomez R, Yoon BH, Thaler HT, Rotmensch S, Romero R. Failure of physiological transformation of the spiral arteries in patients with preterm labor and intact membranes. Am J Obstet Gynecol 2003;189:1063-1069.

  180. Kornick C, Kilborn M, Santiago-Palma J, Schulman G, Thaler H, Keefe D, Katchman A, Pezzullo J, Ebert S, Woosley R, Payne R, Manfredi P. QTc interval prolongation with intravenous methadone. Pain 2003;105:499-506.

  181. Zakian KL, Shukla-Dave A, Meyers P, Gorlick R, Healey J, Thaler HT, Huvos AG, Panicek DM, Koutcher JA. Identification of prognostic markers in bone sarcomas using proton-decoupled phosphorus magnetic resonance spectroscopy. Cancer Res 2003;63:9042-9047.

  182. Gonzales GR, Tuttle SL, Thaler HT, Manfredi PL. Central Pain in Cancer Patients. J Pain 2003;4:351-354.

  183. Moore KH, Thaler HT, Tan LK, Borgen PI, Cody III, HS. Immunohistochemically detected tumor cells in the sentinel lymph nodes of patients with breast carcinoma. Biologic metastasis or procedural artifact? Cancer 2004;100:929-934.

  184. Correa DD, DeAngelis LM, Shi W, Thaler H, Glass A, Abrey LE. Cognitive functions in survivors of primary central nervous system lymphoma (PCNSL). Neurology 2004;62:548-555.

  185. Bernick PE, Klimstra DS, Shia J, Minsky B, Saltz L, Shi W, Thaler H, Guillem J, Paty P, Cohen AM, Wong WD. Neuroendocrine Carcinomas of the Colon and Rectum. Neuroendocrine carcinomas of the colon and rectum. Dis Colon Rectum. 2004 47:163-9.

  186. Covey AM, Gandhi R, Brody LA, Getrajdman G, Thaler HT, Brown KT. Factors associated with pneumothorax following percutaneous lung biopsy in 443 consecutive patients. J Vasc Interv Radiol 2004;15:479-483.

  187. Basch EM, Thaler H, Shi W, Yakren S, Schrag D. Use of information resources by cancer patients and their companions. Cancer 2004;100:2476-2483.

  188. Dupont J, Tanwar MK, Thaler HT, Fleisher M, Kauff N, Hensley ML, Sabbatini P, Anderson S, Aghajanian C, Holland EC, Spriggs DR. Early Detection and Prognosis of Ovarian Cancer Using Serum YKL-40. J Clin Oncol 2004; 22: 3330-3339..

  189. Kalish RB, McCullough L, Gupta M, Thaler HT, Chervenak FA. Intrapartum elective cesarean delivery: A previously unrecognized clinical entity. Obstetr Gynecol 2004;103:1137-1141

  190. Dupont J, Wang X, Marchall DS, Leitao M, Hedvat CV, Hummer A, Thaler H, O’Reilly RJ, Soslow R. Wilms tumor gene (WT1) and p53 expression in ovarian and endometrial carcinomas: a study of 217 cases using tissue microarrays. Gynecol Oncol 2004;94:449-455.

  191. Moore DH, Blessing JA, McQuellon RP, Thaler HT, Cella D, Benda J, Miller DS, Olt G, King S, Boggess JF, Rocereto TF. Phase III study of cisplatin with or without paclitaxel in stage IVB, recurrent or persistent squamous cell carcinoma of the cervix: a gynecologic oncology group study. J Clin Oncol 2004;22:3113-3119.193.

  192. Amar D, Shi W, Hogue CW, Zhang H, Passman RS, Thomas B, Bach PB, Damiano R, Thaler HT. Clinical prediction rule for atrial fibrillation after coronary artery bypass grafting. J Amer Col Card 2004;44:1248-1253.

  193. Wreesmann VB, Shi W, Thaler HT, Poluri A, Kraus DH, Pfister D, Shaha AR, Shah JP, Rao PH, Singh B. Identification of novel prognosticators of outcome in squamous cell carcinoma of the head and neck. J Clin Oncol 2004;22:3965-3972.

  194. Kalish RB, Thaler HT, Chasen ST, Gupta M, Berman SJ, Rosenwaks Z, Chervenak FA. First- and second-trimester ultrasound assessment of gestational age. Am J Obstet Gynecol 2004;191:975-978.

  195. Chang VT, Hwang SS, Thaler HT, Kasimis B, Portenoy RK. The Memorial symptom assessment scale. Expert Review of Pharmacoeconomics and Outcomes Research 2004;4:171-178.

  196. Chang VT, Hwang SS, Kasimis B, Thaler HT. Shorter symptom assessment instruments: the condensed Memorial symptom assessment scale (CMSAS). Cancer Invest 2004;22:526-53.

  197. Darvishian F, Hummer AJ, Thaler HT, Bhargava R, Linkov I, Asher M, Soslow RA. Serous endometrial cancers that mimic endometrioid adenocarcinomas: a clinicopathologic and immunohistochemical study of a group of problematic cases. Am J Surg Pathol 2004;28:1568-78.

  198. Pucar D, Koutcher JA, Sha A, Dyke JP, Schwartz L, Thaler H, Kurhanewica J, Scardino PT, Kelly WK, Hricak H, Zakian KL. MRSI in predicting pathologic stage and PSA relapse in high-risk prosate cancer patients treated with aggressive neoadjuvant therapy prior to radical prostatectomy or radiation therapy. Clin Prostate Cancer 2004;3:174-181.

  199. Araten DJ, Thaler HT, Luzzatto L. High incidence of thrombosis in African-American and Latin- American patients with paroxysmal nocturnal hemoglobinuria. Thromb Haemost 2005;93:88-91.

  200. Patel MI, Subbaramaiah K, Du B, Chang M, Yang P, Newman RA, Cordon-Cardo C, Thaler HT, Dannenberg AJ. Celecoxib inhibits prostate cancer growth. Evidence of a COX-2 independent mechanism. Clin Cancer Res 2005; 11:1999-2007.

  201. Gollub MJ, Jhaveri S, Schwartz E, Felderman H, Cooper C, Markowitz AJ, Kurtz RC, Thaler H. CT colonography features of sigmoid diverticular disease. Clin Imaging 2005;3:200-6

  202. Bhargava R, Shia J, Hummer AJ, Thaler HT, Tornos C, Soslow RA. Distinction of endometrial stromal sarcomas from ’hemangiopericytomatous’ tumors using a panel of immunohistochemical stains. Mod Pathol 2005; 1: 40-47.

  203. Altorki NK, Port JL, Zhang F, Golijanin D, Thaler HT, Duffield-Lillico AJ, Subbaramaiah K, Dannenberg AJ. Chemotherapy induces the expression of cyclooxygenase-2 in non-small cell lung cancer. Clin Cancer Res. 2005;11:4191-7.

  204. Temple LKF, Bacik J, Savatta S, Gottesman L, Paty P, Weiser M, Guillem J, Minsky BD, Kalman M, Thaler HT, Schrag D, Wong WD. The development of a validated instrument to evaluate bowel function after sphincter preserving surgery for rectal cancer. Dis Colon Rectum 2005:48:1353-65.

  205. Barrera R, Shi W, Amar D, Thaler HT, Gabovich N, Bains MS, White DA. Smoking and timing of cessation: impact on pulmonary complications after thoracotomy. Chest 2005; 127:1977-83.

  206. Zakian K, Thaler HT, Fong Y, Koutcher J. Liver regeneration in man is characterized by significant changes in cellular phosphorous metabolism: assessment using proton-decoupled 31P - magnetic resonance spectroscopic imaging. Magn Reson Med. 2005; 54:264-71.

  207. Araten DJ, Golde DW, Zhang RH, Thaler HT, Gargiulo L, Notaro R, Luzzatto L. A quantitative measurement of the human somatic mutation rate. Cancer Res 2005; 65:8111-7.

  208. Pinto JT, Van Raamsdonk J, Leavitt BR, Hayden MR, Thaler HT, Krasnikov BF, Cooper AJL. Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease. J Neurochem. 2005; 94:1087-101.

  209. Amar D, Zhang H, Heerdt PM, Park B, Fleisher M, Thaler HT. Statin use is associated with a reduction in a trial fibrillation after thoracic surgery independent of C-reactive protein. Chest 2005;128:3421-7.

  210. Howe LR, Chang S, Tolle KC, Dillon R, Young LJT, Newman RA, Yang P, Thaler HT, Muller WJ, Brown AMC, Hla T, Subbaramaiah K, Dannenberg AJ. HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in Cox-2-deficient mice. Cancer Res 2005;65: 10113-9.

  211. McQuellon, RP, Thaler, HT, Cella, D, Moore, DH. Quality of Life (QOL) Outcomes from a randomized trial of cisplatin versus cisplatin plus paclitaxel in advanced cervical cancer. Gynecol Oncol. 2006;101:296-304.

  212. Hensley ML, Correa DD, Thaler H, Wilton A, Venkatraman E, Sabbatini P, Chi D; Dupont J, Spriggs D, Aghajanian C, Phase I/II study of weekly paclitaxel plus carboplatin and gemcitabine as first-line treatment of advanced -stage ovarian cancer: pathologic complete response and longitudinal assessment of impact on cognitative functioning. Gynecol Oncol. 2006;102:270-7.

  213. Halpern NA, Pastores SM, Thaler HT, Greenstein RJ, Changes in critical care beds and occupancy in the United States 1985-2000. Differences attributable to hospital size. Crit Care Med. 2006;34:2105-2112.

  214. Amar D, Goenka A, Zhang H, Park B, Thaler HT. Leukocytosis and increased risk of atrial fibrillation after general thoracic surgery. Ann Thorac Surg. 2006;82: 1057-61.

  215. Correa DD, DeAngelis LM, Shi W, Thaler HT, Lin M, Abrey LE, Cognitive functions in low grade gliomas: disease and treatment effects. J Neurooncol. 2007;81:175-84

  216. Gilheeney SW, Lyden DC, Sgouros S, Antunes N, Gerald W, Kramer K, Lis E, Meyers P, Rosen N, Thaler HT, Trippett T, Wexler L, Dunkel IJ, A phase II trial of thalidomide and cyclophosphamide in patients with recurrent or refractory pediatric malignancies. Pediatr Blood Cancer 2007;49 :261-5.

  217. Sabbatini P, Mooney D, Iasonos A, Thaler HT, Aghajanian C, Hensley M, Tew W, Konner, J, Spriggs D, Abu-Rustum N, Dupont J. CA-125 Fluctuations in Patients with Recurrent Ovarian Cancer Receiving Chemotherapy. International Journal of Gynecological Cancer. 2007;17: 589-94

  218. Diefenbach CS, Shah Z, Iasonos A, Barakat RR, Levine DA, Aghajanian C, Sabbatini P, Hensley ML, Konner J, Tew W, Spriggs D, Fleisher M, Thaler H, Dupont J. Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer. Gynecol Oncol 2007;104(2):435-42.

  219. Halpern NA, Pastores SM, Thaler HT, Greenstein RJ. Critical care medicine use and cost by medicare beneficiaries 1995-2000: Major discrepancies among two US Federal Medicare databases. Crit Care Med. 2007; 25:692-697.

  220. Weinstein H, Bates AT, Spaltro BE, Thaler HT, Steingart RM. Influence of Preoperative Exercise Capacity on Length of Stay After Thoracic Cancer Surgery. The Annals of Thoracic Surgery. 2007;84: 197-202

  221. Toth M, Patton DL, Esquenazi B, Earle J, Vele O, Shevuchk M, Thaler HT. Association between Chlamydia trachomatis and abnormal uterine bleeding (AUB). Am J Reprod Immunol. 2007; 57:361-366.

  222. Amar D, Zhang H, Park B, Heerdt PM, Fleisher M, Thaler HT. Inflammation and outcome after general thoracic surgery. European Journal of Cardio-thoracic Surgery. 2007; 32:431-4

  223. Gross ND, Boyle JO, Du B, Lantowski A, Thaler HT, Weksler BB, Subbaramaiah K, Dannenberg AJ. Inhibition of Jun N-terminal Kinases Suppresses the Growth of Experimental Head and Neck Squamous Cell Carcinoma. Clinical Cancer Research. 2007; 13:5910-17

  224. Correa DD, Shi W, Thaler HT, Cheung AM, DeAngelis LM, Abrey LE. Longitudinal cognitive follow-up in low grade gliomas. J Neurooncol. 2008 Feb;86(3):321-7. Epub 2007.

  225. Miyagawa T, Gogiberdze G, Serganova I, Cai S, Balatoni JA, Thaler HT, Ageyeva L, Pillarsetty N, Finn RD, Blasberg RG. Imaging of HSV-tk reporter gene expression: A Comparison between [18F]FEAU, [18F]FFEAU and other imaging probes. J Nucl Med. 2008 Apr;49(4):637-48. Epub 2008 Mar 14.

  226. Amar D, Desiderio DP, Heerdt PM, Kolker AC, Zhang H, Thaler HT. Practice patterns in choice of left double-lumen tube size for thoracic surgery. Anesth Analg. 2008 Feb;106(2):379-83.

  227. Kurihara N, Fan K, Thaler HT, Yang K, Lipkin M. Effect of a Western-style diet fortified with increased calcium and vitamin D on mammary gland of C57BL/6 mice. J Med Food. 2008 Jun;11(2):201-6.

  228. Moroz E, Carlin S, Dyomina K, Burke S, Thaler HT, Blasberg R, Serganova I. Real-time imaging of HIF-1alpha stabilization and degradation. PLoS One. 2009;4(4):e5077. Epub 2009 Apr 4. [PubMed Abstract]

  229. Voigt LP, Pastores SM, Raoof ND, Thaler HT, Halpern NA. Review of a large clinical series: intrahospital transport of critically ill patients: outcomes, timing, and patterns. J Intensive Care Med. 2009 Mar-Apr;24(2):108-15. Epub 2009 Feb 2.

  230. Shukla-Dave A, Lee N, Stambuk H, Wang Y, Huang W, Thaler HT, Patel SG, Shah JP, Koutcher JA. Average arterial input function for quantitative dynamic contrast enhanced magnetic resonance imaging of neck nodal metastases. BMC Med Phys. 2009 Apr 7;9:4. [PubMed Abstract]

  231. Fontes ML, Amar D, Kulak A, Koval K, Zhang H, Shi W, Thaler H. Increased preoperative white blood cell count predicts postoperative atrial fibrillation after coronary artery bypass surgery. J Cardiothorac Vasc Anesth. 2009 Aug;23(4):484-7. Epub 2009 Apr 10.

  232. Serganova I, Moroz E, Vider J, Gogiberidze G, Moroz M, Pillarsetty N, Doubrovin M, Minn A, Thaler HT, Massague J, Gelovani J, Blasberg R. Multimodality imaging of TGFbeta signaling in breast cancer metastases. FASEB J. 2009 Aug;23(8):2662-72. Epub 2009 Mar 26. [PubMed Abstract]

  233. Amar D, Munoz D, Shi W, Zhang H, Thaler HT. A Clinical Prediction Rule for Pulmonary Complications After Thoracic Surgery for Primary Lung Cancer. Anesth Analg. 2009 Oct 27. [Epub ahead of print]

  234. Nagula S, Ishill N, Nash C, Markowitz AJ, Schattner MA, Weiser MR, Temple L, Zauber A, Thaler HT, Gerdes H. Quality of Life and Symptom Control after Stent Placement or Surgical Palliation of Malignant Colorectal Obstruction. Journal of the American College of Surgeons. (in Press)

  235. Correa DD, Zhou Q, Thaler HT, Maziarz M, Hurley K, Hensley ML. Cognitive functions in long-term survivors of ovarian cancer. Gynecol Oncol. 2010 Nov;119(2):366-9. Epub 2010 Jul 14.

  236. Zang X, Sullivan PS, Soslow RA, Waitz R, Reuter VE, Wilton A, Thaler HT, Arul M, Slovin SF, Wei J, Spriggs DR, Dupont J, Allison JP. Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas. Mod Pathol. 2010 Aug;23(8):1104-12. Epub 2010 May 21.

  237. Halpern NA, Pastores SM, Chou JF, Chawla S, Thaler HT. Advance directives in an oncologic  intensive care unit: a contemporary analysis of their frequency, type, and impact. J Palliat Med. 2011 Apr;14(4):483-9. Epub 2011 Mar 18.

  238. Moroz MA, Huang R, Kochetkov T, Shi W, Thaler H, de Stanchina E, Gamez I, Ryan RP, Blasberg RG. Comparison of corticotropin-releasing factor, dexamethasone, and temozolomide: treatment efficacy and toxicity in U87 and C6 intracranial gliomas. Clin Cancer Res. 2011 May 15;17(10):3282-92. Epub 2011 Mar 8.

  239. Shukla-Dave A, Lee NY, Jansen JF, Thaler HT, Stambuk HE, Fury MG, Patel SG, Moreira AL, Sherman E, Karimi S, Wang Y, Kraus D, Shah JP, Pfister DG, Koutcher JA. Dynamic contrast-enhanced magnetic resonance imaging as a predictor of outcome in head and neck squamous cell carcinoma patients with nodal metastases.  Int J Radiat Oncol Biol Phys. 2011 May 19. [Epub ahead of print]

  240. Yaligar J, Thakur SB, Bokacheva L, Carlin S, Thaler HT, Rizwan A, Lupu ME, Wang Y, Matei CC, Zakian KL, Koutcher JA. Lactate MRSI and DCE MRI as surrogate markers of prostate tumor aggressiveness. NMR Biomed. 2012 Jan;25(1):113-22. doi: 10.1002/nbm.1723. Epub 2011 May 25.

  241. Raman T, Roistacher N, Liu J, Zhang H, Shi W, Thaler HT, Amar D. Preoperative left atrial dysfunction and risk of postoperative atrial fibrillation complicating thoracic surgery. J Thorac Cardiovasc Surg. 2012 Feb;143(2):482-7. Epub 2011 Sep 28.

  242. Iasonos A, Sabbatini P, Spriggs DR, Aghajanian CA, O’Cearbhaill RE, Hensley ML, Thaler HT. Identifying clinical improvement in consolidation single-arm phase 2 trials in patients with ovarian cancer in second or greater clinical remission. Int J Gynecol Cancer. 2012 Jan;22(1):63-9.

  243. Correa DD, Shi W, Abrey LE, Deangelis LM, Omuro AM, Deutsch MB, Thaler HT. Cognitive functions in primary CNS lymphoma after single or combined modality regimens. Neuro Oncol. 2012 Jan;14(1):101-8. Epub 2011 Oct 19. [PubMed Abstract]

  244. Konner JA, Grabon DM, Gerst SR, Iasonos A, Thaler H, Pezzulli SD, Sabbatini PJ, Bell-McGuinn KM, Tew WP, Hensley ML, Spriggs DR, Aghajanian CA. Phase II study of intraperitoneal paclitaxel plus cisplatin and intravenous paclitaxel plus bevacizumab as adjuvant treatment of optimal stage II/III epithelial ovarian cancer. J Clin Oncol. 2011 Dec 10;29(35):4662-8. Epub 2011 Nov 7.

  245. Gardner GJ, Baser RE, Brady MF, Bristow RE, Markman M, Spriggs D, Thaler HT. CA125 regression in ovarian cancer patients treated with intravenous versus intraperitoneal platinum-based chemotherapy: A gynecologic oncology group study.  Gynecol Oncol. 2012 Feb;124(2):216-20. Epub 2011 Oct 25.

  246. Araten DJ, Notaro R, Thaler HT, Kernan N, Boulad F, Castro-Malaspina H, Small T, Scaradavou A, Magnan H, Prockop S, Chaffee S, Gonsky J, Thertulien R, Tarquini R, Luzzatto L. Thrombolytic therapy is effective in paroxysmal nocturnal hemoglobinuria: a series of 9 patients and a review of the literature. Haematologica. 2011 Dec 1. [Epub ahead of print]


  1. Thaler HT: The Effect of Covariates on Outcome Measures in Analgesic Clinical Trials. In: Advances in Pain Research and Therapy (Vol 18): Innovations in the Design of Analgesic Clinical Trials.  Max M, Portenoy R, and Laska E, Eds. Raven Press, New York, 1991.

  2. Bookbinder M,  Kiss M, Coyle N, Brown M, Gianella A, Thaler H.  Improving pain management practices. In: Cancer Pain Management (2nd Edition, pp 321-361).  McGuire D, Yarbro C, Ferrel B, Eds, Boston: Jones and Bartlett, 1995.

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