Gene Editing & Screening: Publications

Ralph Garippa (Core Head)

Zhang YM, Zimmer MA, Guardia T, Callahan SJ, Mondal C, Di Martino J, Takagi T, Fennell M, Garippa R, Campbell NR, Bravo-Cordero JJ, White RM. 2018 “Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2.” Dev Cell. 2018 Jun 4;45(5):580-594.e7.

 

Liu HY, Tuckett AZ, Fennell MGarippa R, Zakrzewski JL. 2018 “Repurposing of the CDK inhibitor PHA-767491 as a NRF2 inhibitor drug candidate for cancer therapy via redox modulation.” Invest New Drugs. 2018 Jan 3.

 

Vu LP, Prieto C, Amin EM, Chhangawala S, Krivtsov A, Calvo-Vidal MN, Chou T, Chow A, Minuesa G, Park SM, Barlowe TS, Taggart J, Tivnan P, Deering RP, Chu LP, Kwon JA, Meydan C, Perales-Paton J, Arshi A, Gönen M, Famulare C, Patel M, Paietta E, Tallman MS, Lu Y, Glass J, Garret-Bakelman FE, Melnick A, Levine R, Al-Shahrour F, Järås M, Hacohen N, Hwang AGarippa R, Lengner CJ, Armstrong SA, Cerchietti L, Cowley GS, Root D, Doench J, Leslie C, Ebert BL, Kharas MG. 2017 “Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells.” Nat Genet. 2017 Jun;49(6):866-875

 

Mondello P, Brea EJ, De Stanchina E, Toska E, Chang AY, Fennell M, Seshan V, Garippa R, Scheinberg DA, Baselga J, Wendel HG, Younes A. 2017 “Panobinostat acts synergistically with ibrutinib in diffuse large B cell lymphoma cells with MyD88 L265 mutations.” JCI Insight. 2017 Mar 23;2(6):e90196.

 

Pelossof R, Fairchild L, Huang CH, Widmer C, Sreedharan VT, Sinha N, Lai DY, Guan Y, Premsrirut PK, Tschaharganeh DF, Hoffmann T, Thapar V, Xiang Q, Garippa RJ, Rätsch G, Zuber J, Lowe SW, Leslie CS, Fellmann C. 2017 “Prediction of potent shRNAs with a sequential classification algorithm.” Nat Biotechnol. 2017 Apr;35(4):350-353.

 

Kim IS, Heilmann S, Kansler ER, Zhang Y, Zimmer M, Ratnakumar K, Bowman RL, Simon-Vermot T, Fennell M, Garippa R, Lu L, Lee W, Hollmann T, Xavier JB, White RM. 2017 “Microenvironment-derived factors driving metastatic plasticity in melanoma.” Nat Commun. 2017 Feb 9;8:14343.

 

Brea EJ, Oh CY, Manchado E, Budhu S, Gejman RS, Mo G, Mondello P, Han JE, Jarvis CA, Ulmert D, Xiang Q, Chang AY, Garippa RJ, Merghoub T, Wolchok JD, Rosen N, Lowe SW, Scheinberg DA. 2016 “Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells.” Cancer Immunol Res. 2016 Nov;4(11):936-947. 

 

Olejniczak SH, La Rocca G, Radler MR, Egan SM, Xiang Q, Garippa R, Thompson CB. 2016 “Coordinated Regulation of Cap-Dependent Translation and MicroRNA Function by Convergent Signaling Pathways.” Mol Cell Biol. 2016 Aug 26;36(18):2360-73.

 

Miles LA, Garippa RJ, Poirier JT. 2016 “Design, execution, and analysis of pooled in vitro CRISPR/Cas9 screens.” FEBS J. 2016 Sep;283(17):3170-80.

 

Tschaharganeh DF, Lowe SW, Garippa RJ, Livshits G. 2016 “Using CRISPR/Cas to study gene function and model disease in vivo.” FEBS J. 2016 Sep;283(17):3194-203.

 

Fennell M, Commisso C, Ramirez C, Garippa R, Bar-Sagi D. 2015 “High-content, full genome siRNA screen for regulators of oncogenic HRAS-driven macropinocytosis.” Assay Drug Dev Technol. 2015 Sep;13(7):347-55.

 

Fennell M, Xiang Q, Hwang A, Chen C, Huang CH, Chen CC, Pelossof R, Garippa RJ. 2014 “Impact of RNA-guided technologies for target identification and deconvolution.” J Biomol Screen. 2014 Dec;19(10):1327-37.