Recent MSK Discoveries & Advances

Memorial Sloan Kettering researchers are relentlessly exploring every aspect of cancer — from basic investigations of cells and molecules to clinical trials of new treatments and population-wide studies of the disease. While our core mission is to translate this knowledge into new strategies to control cancer, many of our investigators are also making scientific progress against other diseases and conditions.

Below are some examples of discoveries and advances that recently were made in our laboratories and clinics, and featured in our blog, On Cancer.

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In the Lab

Drug That Hits CAR T Snooze Button Can Quiet a Cytokine Storm

An FDA-approved drug used to treat leukemia can serve as a temporary off switch for CAR T cells, MSK scientists have found.

cartoon of man hitting a snooze button

In the Lab

Scientists Use CRISPR to Learn How Cells Make Decisions

The genome-editing technique uncovered several genes previously not known to influence embryonic development.

Fluorescent red and green cells

In the Lab

Research Clarifies How IDH Mutations Cause Cancer

The MSK team’s goal was to get at the underlying defects in cells that these mutations cause.

DNA winding around histones

In the Lab

Researchers Unravel the Biology of a Distinct Prostate Cancer Subtype

Mutations in a gene called FOXA1 are responsible for a distinct class of prostate cancer tumors, MSK researchers have found.

MSK cancer researchers Elizabeth Adams, Charles Sawyers, and Rohit Bose

In The Lab

Ro Versus Musashi: How One Molecule Can Turn Cancer Cells Back to Normal

Researchers identify a compound that appears to eliminate tumor cells in a dish and in mice.

An illustration of a samurai and a crab.

In the Lab

Checkpoint Challenge: When Releasing Immune Cell Brakes Is Not Enough to Stop Cancer

Scientists have learned that cutting a T cell’s brakes can have unexpected consequences.

Immune cells surrounding a cancer cell

In The Lab

Computational “Hive Mind” Helps Scientists Solve an Enzyme’s Cryptic Movements

The breakthrough gives an unprecedented look at the varied and shifting poses of a protein in action.

Two clusters of colored blobs with a diagram in the middle

Roundup

Highlights from ASCO 2019: Progress in Treating Cancer in Children

MSK Kids doctors report advances in treating pediatric cancers at the 2019 meeting of the American Society of Clinical Oncology.

Crowd shot at ASCO 2019

In The News

ASCO 2019: PARP Inhibitors Benefit People with Pancreatic Cancer Who Have a BRCA Mutation

Results from a large phase III clinical trial unveiled at this year’s ASCO meeting identify an effective targeted therapy for a subset of people with pancreatic cancer.

MSK medical oncologist Eileen O'Reilly with a patient

Q & A

What Can Be Learned from a Negative Clinical Trial? Findings from a Sarcoma Study at ASCO 2019

At the ASCO meeting in Chicago, MSK medical oncologist William Tap talked about disappointing results from a new sarcoma drug, which didn’t increase survival.

Medical oncologist William Tap