Organoid cultures recapitulated the adenocarcinoma features, and IHC showed the cells were diffusely positive for AR and pan-cytokeratin, matching the tumor sample. When grafted into the renal capsule of SCID mice, the tumors were histologically indistinguishable from the metastatic lesion and stained diffusely positive for pan-cytokeratin and AR. The established organoid line exhibits a double time of 3 days.
MSK-PCa2 is derived from patient who presented with metastatic adenocarcinoma. He had a short-term response to ADT for 6-months and developed an expanding hip metastasis requiring arthroplasy.
- Yu Chen, MD, PhD, Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Dong Gao, PhD, formerly at Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center
Gao D, et al. Organoid Cultures Derived from Patients with Advanced Prostate Cancer. Cell, 2014;159(1):176-87.
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