The organoids from the biopsy showed a similar mucinous histology that was diffusely positive for AR and pan-cytokeratin. When grafted into mice, the tumor exhibited the identical histology as well as positivity for AR and pan-cytokeratin. The established organoid line exhibits a double time of 1 week.
MSK-PCa3 is derived from a patient who presented with metastatic prostate cancer to the pelvic lymph nodes with a diagnosis PSA of only 1.53 ng/dl. Biopsy showed adenocarcinoma with mucinous features that was positive for AR but negative for PSA. Despite a PSA response to <0.05 ng/dl, the patient progressed radiographically and a second biopsy was performed.
- Yu Chen, MD, PhD, Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Dong Gao, PhD, formerly at Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center
Gao D, et al. Organoid Cultures Derived from Patients with Advanced Prostate Cancer. Cell, 2014;159(1):176-87.
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