Description
Organoids from the lymph node showed adenocarcinoma cribriform growth pattern (Gleason pattern 4) that was diffusely positive for AR and pan-cytokeratin, matching the tumor tissue. The established organoid line exhibits a double time of 3 weeks.
Source
MSK-PCa7, the only sample from clinically hormone-sensitive disease, is developed from a patient who underwent prostatectomy for Gleason 4+3 adenocarcinoma. He developed metastatically a single, radiographically enlarged, pelvic lymph node and underwent surgical resection of the lymph node.
Inventors
- Yu Chen, MD, PhD, Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Dong Gao, PhD, formerly at Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center
Key References
Gao D, et al. Organoid Cultures Derived from Patients with Advanced Prostate Cancer. Cell, 2014;159(1):176-87.
Licensing Information
This organoid cell line may be licensed nonexclusively for research or commercial purposes.
Contact Information
For licensing requests: Alexandra Buga, MBA, Licensing Manager, Office of Technology Development, MSK, 646-888-1078, bugaa@mskcc.org.