Organoids from the lymph node showed adenocarcinoma cribriform growth pattern (Gleason pattern 4) that was diffusely positive for AR and pan-cytokeratin, matching the tumor tissue. The established organoid line exhibits a double time of 3 weeks.
MSK-PCa7, the only sample from clinically hormone-sensitive disease, is developed from a patient who underwent prostatectomy for Gleason 4+3 adenocarcinoma. He developed metastatically a single, radiographically enlarged, pelvic lymph node and underwent surgical resection of the lymph node.
- Yu Chen, MD, PhD, Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Dong Gao, PhD, formerly at Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center
Gao D, et al. Organoid Cultures Derived from Patients with Advanced Prostate Cancer. Cell, 2014;159(1):176-87.
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