MSK-PCa7: Human Prostate Cancer Organoids

Description

Organoids from the lymph node showed adenocarcinoma cribriform growth pattern (Gleason pattern 4) that was diffusely positive for AR and pan-cytokeratin, matching the tumor tissue. The established organoid line exhibits a double time of 3 weeks.

Source

MSK-PCa7, the only sample from clinically hormone-sensitive disease, is developed from a patient who underwent prostatectomy for Gleason 4+3 adenocarcinoma. He developed metastatically a single, radiographically enlarged, pelvic lymph node and underwent surgical resection of the lymph node.

Inventors

  • Yu Chen, MD, PhD,  Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center
  • Dong Gao, PhD, formerly at Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center

Key References

Gao D, et al. Organoid Cultures Derived from Patients with Advanced Prostate Cancer. Cell,  2014;159(1):176-87.

Licensing Information

This organoid cell line may be licensed nonexclusively for research or commercial purposes.

Contact Information

For licensing requests: Alexandra Buga, MBA, Licensing Associate, Office of Technology Development, MSK, 646-888-1078, bugaa@mskcc.org.

Stage of Development

Ready to use

Indications