Our mission is the development of a “new” generation of optical imaging technologies to enable advances in two hitherto difficult-to-investigate areas: the real-time analysis of macromolecular interactions and motions at the nanometer scale in vivo and the three-dimensional architecture of complex molecular machines and of subcellular ultrastructure, in situ. We are also refining and applying ultrahigh-resolution spectroscopy techniques to dissect multistep complex biochemical processes using in vitro reconstituted single-molecule assays.
Alexandros Pertsinidis, PhD
Research FocusStructural biologist Alexandros Pertsinidis uses structural molecular and structural cell biology to study novel optical imaging and spectroscopy technologies to understand the function of complex macromolecular machines inside living cells.
EducationPhD, Brown University
- Pertsinidis A, Zhang Y, Chu S. Subnanometre single-molecule localization, registration and distance measurements. Nature. 2010 Jul 29;466(7306):647-51. doi: 10.1038/nature09163. Epub 2010 Jul 7.
- Guanshi Wang, Jesse Hauver, Zachary Thomas, Seth A. Darst, Alexandros Pertsinidis. Single-Molecule Real-Time 3D Imaging of the Transcription Cycle by Modulation Interferometry. Cell. Volume 167, Issue 7, p1839–1852.e21, 15 December 2016
- Director’s New Innovator Award, National Institutes of Health (2012)