One of the most exciting discoveries of the last two decades has been the identification of a large number of non-coding RNAs and the realization that they play essential roles in mammalian development and in diseases. Their study and the characterization of their contribution to the pathogenesis of human cancer is the central focus of our group.
Andrea Ventura, MD, PhD
Research FocusCancer biologist Andrea Ventura studies non-coding RNAs in cancer and development
- MD, Catholic University of Rome (Italy)
- PhD, European Institute of Oncology (Milan Italy), Open University (London, UK)
- Han YC, Vidigal JA, Mu P, Yao E, Singh I, González AJ, Concepcion CP, Bonetti C, Ogrodowski P, Carver B, Selleri L, Betel D, Leslie C, Ventura A. An allelic series of miR-17～92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron. Nat Genet. 2015 Jun 1. doi: 10.1038/ng.3321. [Epub ahead of print] PubMed PMID: 26029871.
- Danilo Maddalo, Eusebio Manchado, Carla P. Concepcion, Ciro Bonetti, Joana A. Vidigal, Yoon-Chi Han, Paul Ogrodowski, Alessandra Crippa, Natasha Rekhtman, Elisa de Stanchina, Scott W. Lowe, and Andrea Ventura. In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system. Nature. 2014 Oct 22.