My laboratory has combined biochemical, molecular, cellular, and genetic approaches to investigate the roles of CDK inhibitors in differentiation, development, and cancer biology. An additional major focus of the laboratory is directed towards understanding how these gene products are regulated to accomplish these roles.
Andrew Koff, PhD
Research FocusMolecular biologist Andrew Koff investigates the role of cell cycle inhibitors in differentiation and how their loss affects tumorigenesis.
EducationPhD, State University NY at Stony Brook
- Deb S., DeLucia AL, Baur CP, Koff A, and Tegtmeyer P. Domain structure of the simian virus 40 core origin of replication. Mol. Cell Biol. 6:1663-1670, 1986.
- Deb S, DeLucia AL, Koff A, Tsui S, and Tegtmeyer P. The adenine-thymine domain of the simian virus 40 core origin directs DNA bending and coordinately regulates DNA replication. Mol. Cell Biol. 6:4578-4584, 1986.