Our lab aims to identify the mechanisms that regulate lymphatic function in pathologic and physiologic conditions. We have developed a number of novel animal models that enable us to study how lymphatic vessels regenerate during wound repair and how this process is regulated by pro- and anti-lymphangiogenic mechanisms. Our studies have focused on the role of T cell–mediated inflammatory reactions and have shown that these immune responses regulate lymphatic regeneration and function both directly and indirectly.
- Avraham T, Zampell JC, Yan A, Elhadad S, Weitman ES, Rockson SG, Bromberg J, Mehrara BJ. Th2 differentiation is necessary for soft tissue fibrosis and lymphatic dysfunction resulting from lymphedema. FASEB J. 2013 Mar;27(3):1114-26. doi: 10.1096/fj.12-222695. Epub 2012 Nov 27.
- Zampell JC, Yan A, Elhadad S, Avraham T, Weitman E, Mehrara BJ. CD4(+) cells regulate fibrosis and lymphangiogenesis in response to lymphatic fluid stasis. PLoS One. 2012;7(11):e49940. doi: 10.1371/journal.pone.0049940. Epub 2012 Nov 20.