The Cole Haynes Lab

Mitochondrial dysfunction is associated with multiple pathologies including Parkinson’s disease, cancer, bacterial infection, and metabolic disorders as well as general aging. We investigate how cells adapt to survive the cause of mitochondrial dysfunction and ultimately recover mitochondrial activity.

We primarily focus on an intracellular signaling pathway known as the mitochondrial unfolded protein response (UPRmt).We’ve made significant progress towards understanding how cells monitor mitochondrial function and adapt transcription accordingly if the mitochondrial pool is compromised. Cells simply monitor mitochondrial protein import efficiency using the transcription factor ATFS-1 as a sentinel.

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The Cole Haynes Lab

Cole Haynes, PhD

Associate Professor

Research Focus

Cell biologist Cole Haynes focuses on the molecular mechanisms of mitochondrial function during development, aging, and cancer cell growth.
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Education

  • PhD, University of Missouri Kansas City

Lab Members

Career Opportunities

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