Mitochondrial dysfunction is associated with multiple pathologies including Parkinson’s disease, cancer, bacterial infection, and metabolic disorders as well as general aging. We investigate how cells adapt to survive mitochondrial dysfunction, primarily focusing on an intracellular signaling pathway known as the mitochondrial unfolded protein response (UPRmt).
Cole Haynes, PhD
Research FocusCell biologist Cole Haynes focuses on the molecular mechanisms of mitochondrial function during development, aging, and cancer cell growth.
- PhD, University of Missouri Kansas City
- Pellegrino MW, Nargund AM, Kirienko NV, Gillis R, Fiorese CJ, Haynes CM. Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature. 2014. Sept 28. doi: 10.1038/nature13818
- Haynes CM, Fiorese CJ, Lin YF. Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond. Trends Cell Biol. 2013 Mar 11. pii: S0962-8924(13)00032-9. doi: 10.1016/j.tcb.2013.02.002.
- Bristol-Myers Squibb/James D. Robinson III Junior Faculty Chair (2014)
- Boyer Award in Basic Research (2014)
- Ellison Medical Foundation New Scholar in Aging (2011)
- Gerstner Young Investigator (2010)
- Alfred W. Bressler Scholar (2010)