The Thompson laboratory has proposed that the basis of metazoan cell survival is determined by the inability of cells to take up nutrients in a cell-autonomous fashion. This hypothesis was formulated to explain how multicellularity might have arisen during evolution. We believe the lack of a cell-intrinsic mechanism to regulate nutrient uptake provides the first and most fundamental barrier to cell transformation.
Craig B. Thompson, MD
President and CEO, Memorial Sloan Kettering Cancer Center