We are looking for a molecular biologist/geneticist to develop assays for profiling circulating nucleic acids (DNA/RNA), or so-called “Liquid Biopsy”, in body fluids (plasma, urine, CSF) of different cancer types.
The successful candidate will participate in projects to achieve 3 goals: (1) develop molecular assays to profile circulating tumor DNA (ctDNA) from body fluids and (2) evaluate its utility in different solid cancer types (3) study the biological characteristics of circulating tumor DNA in body fluids. (Research focuses of the lab are here).
For (1), the types of assays we develop include targeted deep sequencing, exome sequencing and whole genome sequencing, depending on tumor types and the genomic coverage/detection sensitivity required for different clinical questions. Prior experience on applying any of these technologies on human tissues (tumor/FFPE) or body fluids (plasma, urine, saliva, CFS) in pregnancy or pathological conditions (not limited to cancer) will be necessary. Understanding of the different molecular strategies for mutation detection and quantification is critical.
For (2 and 3), we work with a variety of solid tumor teams and clinical trial teams across MSKCC to address different questions (examples here – we collect longitudinal samples and aim to compare ctDNA dynamics with clinical responses to evaluate its informatively on treatment decision. The possible cancer types include: prostate, breast, brain, bladder and ovarian, and the list is expanding. Basic understanding of cancer genomics will be necessary.
Assay development will be a jointed effort with the Innovation Laboratory of the Center for Molecular Oncology, Molecular Diagnostics Service team and Department of Laboratory Medicine. Clinical evaluation will be done in close collaboration with individual research groups and clinical trials teams. The ideal candidate will be a team-player with excellent communication and interpersonal skills.
- Nucleic acids extraction (DNA/RNA),
- PCR, digital PCR,
- DNA quantification,
- Library preparation (whole-genome / exome / targeted / DNA methylation) for massively parallel sequencing (next-generation sequencing, NGS), or relevant experience.
Knowledge of biomedical statistics, and experience with statistics programmes such as R, SPSS, Prism, etc.
- Experience with document-processing programmes such as Microsoft Office (Excel, Word, Powerpoint), etc.
- Scientific figures management such as Adobe Illustrator, Inkscape, etc. is a plus
- Experience with programming skill, such as R, Python, MatLab, etc, is a plus.
We are not looking for someone who only follows protocols. We want an inventor with a creative mind. Join us if you think you are good and want to make an impact.
Memorial Sloan Kettering Cancer Center is an equal opportunity employer with a strong commitment to enhancing the diversity of its faculty and staff. Women and applicants from diverse racial, ethnic and cultural backgrounds are encouraged to apply.
More information about postdoctoral training at MSKCC:
If you are interested in joining our lab, please submit your curriculum vitae and a cover letter detailing your past research experience, accomplishments, current motivation and future research interests. Include your expected availability date and the names and contact information of three referees.