The overall goals of this laboratory are to develop novel targeted immunotherapies based on effectors of the immune system and to understand their mechanisms of action as well as the mechanisms of resistance to them. This includes passive agents (antibodies, targeted nano-devices, and ligands) and active agents (vaccines). An important goal is to take these new therapies into human clinical trials for testing.
We have developed alpha particle therapies, targeted beta emitters, oncogene product peptide vaccines, and are presently developing prototype targeted nano-machines. Recently, our lab developed a molecular nanogenerator that releases alpha particles inside cancer cells. This is now being tested in humans. Read full article in Science (Science. 2001;294;1537-1540.).
David A. Scheinberg, MD, PhD
Chair, Molecular Pharmacology & Chemistry Program, SKI; Director, Center for Experimental Therapeutics
Research FocusMolecular Pharmacology and Chemistry Program Chair David Scheinberg focuses on the discovery and development of novel, specific immunotherapeutic agents and targeted nanodevices for cancer therapy.
- MD, PhD, Johns Hopkins University School of Medicine
- Dao T, Yan S, Veomett N, Pankov D, Zhou L, Korontsvit T, Whitten J, Tan T, Liu H, Scott A, Whitten J, Maslak P, Casey E, Tan T, Liu H, Zakhaleva V, Curcio M, Doubrovina E, O’Reilly RJ, Liu C and Scheinberg DA. Targeting the intracellular WT1 oncogene product with a therapeutic human antibody. Sci Transl Med. 2013 Mar 13;5(176):176ra33. doi: 10.1126/scitranslmed.3005661.
- McDevitt MR, Ma, DS, Lai LT, Simon J, Frank RK, Borchardt P, Wu K, Pellegrini V, Curcio MJ, Miederer M, Bander NH, Scheinberg DA. Tumor therapy with targeted atomic nanogenerators. Science. 2001 Nov 16;294(5546):1537-40.