For a review of macrocyclization approaches to target-oriented synthesis, see:

Illuminati G, Mandolini L. Acc Chem Res. 1981;14:95-102.

For a review of ring expansion approaches to target-oriented synthesis, see:

Stach H, Hesse M. Tetrahedron. 1988;44:1573-1590.

For recently reported macrocyclization approaches to diversity oriented synthesis, see:

Lee D, Sello J, Schreiber SL. J Am Chem Soc. 1999;121:10648-10649.

Park C, Burgess K. Facile macrocyclizations to beta-turn mimics with diverse structural, physical, and conformational properties. J Comb Chem. 2001;3:257-266.

For recent reviews of small molecule modulation of protein-protein interactions, see: Berg T. Modulation of protein-protein interactions with small organic molecules. Angew Chem Int Ed Engl. 2003;42:2462-2481.

Gadek TR, Nicholas JB. Small molecule antagonists of proteins. Biochem Pharmacol. 2003;65:1-8.