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Group Meeting Papers 2009

Here is a list of research papers that were presented for discussion in our 2009 weekly group meetings. Papers are selected by group members as a means to broaden our knowledge in chemistry and chemical biology.

7 Dec 2009, presented by Sharanya Rajagopal
Cell-selective metabolic labeling of proteins.
Ngo, J. T.; Champion, J. A.; Mahdavi, A.; Tanrikulu, I. C.; Beatty, K. E.; Connor, R. E.; Yoo, T. H.; Dieterich, D. C.; Schuman, E. M.; Tirrell, D.A.* Nat. Chem. Biol. 2009, 5, 715-717.
[ Abstract ]

23 Nov 2009, presented by Tony Davis
Inhibitors selective for mycobacterial versus human proteasomes.
Lin, G.*; Li, D.; Sorio de Carvalho, L. P.; Deng, H.; Tao, H.; Vogt, G.; Wu, K.; Schneider, J.; Chidawanyika, T.; Warren, J. D.; Li, H.*; Nathan, C.* Nature 2009, 461, 621-626.
[ Abstract ]

9 Nov 2009, presented by Debarshi Pratihar
Enantiodivergent conversion of chiral secondary alcohols into tertiary alcohols.
Stymiest, J. L.; Bagutski, V.; French, R. M.; Aggarwal, V. K.* Nature 2008, 456, 778-782.
[ Abstract ]

26 Oct 2009, presented by Gustavo Moura-Letts
Iron-catalyzed C(sp³)-C(sp³) bond formation through C(sp³)-H functionalization: A cross-coupling reaction of alcohols with alkenes.
Zhang, S.-Y.; Tu, Y.-Q.; Fan, C.-A.; Zhang, F.-M.; Shi, L.* Angew. Chem. Intl. Ed. 2009, 48, 8761-8765.
[ AbstractAbstract ]

5 Oct 2009, presented by Chris Stratton
Synthetic study toward the total synthesis of maoecrystal V.
Gong, J.; Lin, G.; Li, C.-c.*; Yang, Z.* Org. Lett. 2009, 11, 4770-4773.
[ Abstract ]

A synthesis of the carbon skeleton of maoecrystal V.
Krawczuk, P. J.; Schöne, N.; Baran, P. S.* Org. Lett. 2009, 11, 4774-4776.
[ Abstract ]

23 Sep 2009, presented by Shalini Balakrishnan
A chemical screen for biological small molecule-RNA conjugates reveals CoA-linked RNA.
Kowtoniuk, W. E.; Shen, Y.; Heemstra, J. M.; Agarwal, I.; Liu, D. R.* Proc. Natl. Acad. Sci. USA 2009, 106, 7768-7773.
[ Abstract ]

16 Sep 2009, presented by Jackie Wurst
Can one predict changes from SN1 to SN2 mechanisms?
Phan, T. B.; Nolte, C.; Kobayashi, S.; Ofial, A.R.; Mayr, H.* J. Am. Chem. Soc. 2009, 131, 11392-11401.
[ Abstract ]

10 Aug 2009, presented by Renato Bauer
Quantifying biogenic bias in screening libraries.
Hert, J.; Irwin, J. J.; Laggner, C.; Keiser, M. J.; Shoichet, B. K.* Nat. Chem. Biol. 2009, 5, 479-483.
[ Abstract ]

22 Jul 2009, presented by Xuequan Lu
Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition.
Clerc, J.; Groll, M.; Illich, D. J.; Bachmann, A. S.; Huber, R.; Schellenberg, B.; Dudler, R.*; Kaiser, M.* Proc. Natl. Acad. Sci. USA 2009, 106, 6507-6512.
[ Abstract ]

13 Jul 2009, presented by Felix Kopp
Radicals and transition-metal catalysis - An alliance par excellence to increase reactivity and selectivity in organic chemistry.
Ford, L.; Jahn, U.* Angew. Chem. Intl. Ed. 2009, 48, 6386-6389.
[ Abstract ]

29 June 2009, presented by Guodong Liu
Biosynthesis and metabolism of cyclopropane rings in natural compounds.
Wessjohann, L. A.*; Brandt, W. Chem. Rev. 2003, 103, 1625-1647.
[ Abstract ]

2 June 2009, presented by Tony Davis
A small molecule that binds Hedgehog and blocks its signaling in human cells.
Stanton, B. Z.; Peng, L. F.*; Maloof, N.; Nakai, K.; Wang, X.; Duffner, J. L.; Taveras, K. M.; Hyman, J. M.; Lee, S. W.; Koehler, A. N.; Chen, J, K.; Fox, J. L.; Mandinova, A.; Schreiber, S. L.* Nat. Chem. Biol. 2009, 5, 154-156.
[ Abstract ]

18 May 2009, presented by Debarshi Pratihar
Achieving molecular complexity by organocatalytic one-pot strategies - A fast entry for synthesis of sphingoids, amino sugars, and polyhydroxylated α-amino acids.
Jiang, H.; Elsner, P.; Jensen, K. L.; Falcicchio, A.; Marcos, V.; Jørgensen, K. A.* Angew. Chem. Intl. Ed. 2009, 48, 6844-6848.
[ Abstract ]

27 April 2009, presented by Gustavo Moura-Letts
How protein recognizes ladder-like polycyclic ethers: Interactions between ciguatoxin (CTX3C) fragments and its specific antibody 10C9.
Ui, M.; Tanaka, Y.; Tsumuraya, T.; Fujii, I.; Inoue, M.; Hirama, M.; Tsumoto, K.* J. Biol. Chem. 2008, 283, 19440-19447.
[ Abstract ]

13 April 2009, presented by Chris Stratton
Identification of a chemical probe for NAADP by virtual screening.
Naylor, E.; Arredouani, A.; Vasudevan, S. R.; Lewis, A. M.; Parkesh, R.; Mizote, A.; Rosen, D.; Thomas, J. M.; Izumi, M.; Ganesan, A.; Galione, A.; Churchill, G. C.* Nat. Chem. Biol. 2009, 5, 220-226.
[ Abstract ]

30 Mar 2009, presented by Shalini Balakrishnan
Dynamic proteomics of individual cancer cells in response to a drug.
Cohen, A. A.*; Geva-Zatorsky, N.; Eden, E.; Frenkel-Morgenstern, M.; Issaeva, I.; Sigal, A.; Milo, R.; Cohen-Saidon, C.; Liron, Y.; Kam, Z.; Cohen, L.; Danon, T.; Perzov, N.; Alon, U. Science 2008, 322, 1511-1516.
[ Abstract ]

9 Mar 2009, presented by Jackie Wurst
Total synthesis of a chlorosulpholipid cytotoxin associated with seafood poisoning.
Nilewski, C.; Geisser, R. W.; Carreira, E. M.* Nature 2009, 457, 573-576.
[ Abstract ]

19 Jan 2009, presented by Renato Bauer
Self-consistent synthesis of the squalene synthase inhibitor zaragozic acid C via controlled oligomerization.
Nicewicz, D. A.; Satterfield, A. D.; Schmitt, D. C.; Johnson, J. S.* J. Am. Chem. Soc. 2008, 130, 17281-17283.
[ Abstract ]