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Selected Publications (Graphical Abstracts)

Read up on the latest publications in diversity-oriented synthesis, rational drug design, chemical biology, and drug discovery research from the Tan Lab!

Selected Publications: Text Only | Graphical Abstracts
Complete Publications: Text Only | Graphical Abstracts

Full-text versions of articles are available from the publisher with online journal subscription. PubMed Central (PMC) versions of articles are available free of charge.


  1. Family-level stereoselective synthesis and biological evaluation of pyrrolomorpholine spiroketal natural product antioxidants
    Verano, A. L.; Tan, D. S.* Chem. Sci. 2017, 8, 3687–3693.
    Abstract | PubMed | PMC ] Chemical Science 2017 graphical abstract

  2. Stereocontrolled Synthesis of Spiroketals: An Engine for Chemical and Biological Discovery
    Verano, A. L.; Tan, D. S.* Isr. J. Chem. 2017, 57, 279–291.
    Abstract | PubMed | PMC ] Israel Journal of Chemistry 2017 graphical abstract

  3. Designed small-molecule inhibitors of the anthranilyl-CoA synthetase PqsA block quinolone biosynthesis in Pseudomonas aeruginosa.
    Ji, C.; Sharma, I.; Pratihar, I.; Hudson, L.; Maura, D.; Guney, T.; Rahme, L. G.; Pesci, E. C.; Coleman, J. P.; Tan, D. S.* ACS Chem. Biol. 2016, 11, 3061–3067.
    Abstract | PubMed | PMC ]
     ACS Chem. Biol 2016 graphical abstract

  4. Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents.
    Matarlo, J. S.; Evans, C. E.; Sharma, I.; Lavaud, L. J.; Ngo, S. C.; Shek, R.; Rajashankar, K. R.; French, J. B.; Tan, D. S.*; Tonge, P. J.* Biochemistry 2015, 54, 6514–6524.
    Abstract | PubMed | PMC ]
    Biochemistry 2015 graphical abstract

  5. General platform for systematic quantitative evaluation of small-molecule permeability in bacteria.
    Davis, T. D.; Gerry, C. J.; Tan, D. S.* ACS Chem. Biol. 2014, 9, 2535–2544.
    Abstract | PubMed | PMC ]
    ACS Chemical Biology 2014 graphical abstract

    (Highlighted in ACS Chem. Biol.)

  6. Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion.
    Bauer, R. A.; Wenderski, T. A.; Tan, D. S.* Nat. Chem. Biol. 2013, 9, 21–29.
    Abstract | PubMed | PMC ]
    Nature Chemical Biology 2013 graphical abstract

  7. A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion.
    Kopp, F.; Stratton, C. F.; Akella, L. B.; Tan, D. S.* Nat. Chem. Biol. 2012, 8, 358–365.
    Abstract | PubMed | PMC ]
    Nature Chemical Biology 2012 graphical abstract

    (Highlighted in SciBX )

  8. Hydrogen-bonding catalysis and inhibition by simple solvents in the stereoselective kinetic epoxide-opening spirocyclization of glycal epoxides to form spiroketals.
    Wurst, J. M.; Liu, G.; Tan, D. S.* J. Am. Chem. Soc. 2011, 133, 7916–7925.
    Abstract | PubMed | PMC ]
    Journal of the American Chemical Society 2011 graphical abstract

  9. Active site remodelling accompanies thioester bond formation in the SUMO E1.
    Olsen, S. K.; Capili. A. D.; Lu, X.; Tan, D. S.*; Lima, C. D.* Nature 2010, 463, 906–912.
    Abstract | PubMed | PMC ]
    Nature 2010 graphical abstract

    (Highlighted in Nature, Chem. Eng. News, Nat. Rev. Mol. Cell Biol., Nat. Chem. Biol., Structure, ACS Chem. Biol., and Faculty of 1000 Biology )

  10. Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.
    Lu, X.; Olsen, S. K.; Capili, A. D.; Cisar, J. S.; Lima, C. D.*; Tan, D. S.* J. Am. Chem. Soc. 2010, 132, 1748–1749.
    Abstract | PubMed | PMC ]
    Journal of the American Chemical Society 2010 graphical abstract

    (Highlighted in Chem. Eng. News, Nat. Rev. Mol. Cell Biol., ACS Chem. Biol., and Faculty of 1000 Biology )