Our group applies crystallographic and solution NMR techniques to investigate macromolecular-mediated recognition, regulation, and catalysis. The major thrust of the laboratory is currently in the structural biology of RNA silencing and epigenetic regulation (histone and DNA methylation marks). Significant efforts are also under way toward a molecular understanding of RNA-mediated events involving riboswitches and ribozymes, as well as protein-RNA recognition events impacting on disease syndromes. A new project addvesses structure-function studies of cytoplasmic metazoan nucleic acid sensors and their cyclic dinucleotide second messengers that activate the innate immune response. Other projects include higher-order DNA architectures and the DNA damage. Finally, our group also studies the molecular basis of glycosphingolipid and phospholipid binding specificity.
Dinshaw Patel, PhD
Research FocusStructural biologist Dinshaw Patel studies the structural biology of macromolecular recognition, including RNA catalysis, RNA interference, and bypass of DNA damage.
EducationPhD, New York University
- Johnson, L. M., Du, J., Hale, C. J., Bischof, S., Feng, S., Chodavarapu, R. K., Zhong, X., Marson, G., Pellergrini, M., Segal, D. J., Patel, D. J. and Jacobsen, S. E. (2014). SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Nature 507, 124-128.
- Swarts, D. C., Jore, M. M., Westra, E. R., Zhu, Y., Janssen, J. H., Snijders, A. P., Wang, Y., Patel, D. J., Berenguer, J., Brouns, S. J. and van der Oost, J. (2014). DNA-guided DNA interference by prokaryotic Argonaute. Nature 507, 258-261.