The Dinshaw Patel Lab

Our group applies crystallographic and solution NMR techniques to investigate macromolecular-mediated recognition, regulation, and catalysis. The major thrust of the laboratory is currently in the structural biology of RNA silencing and epigenetic regulation (histone and DNA methylation marks). Significant efforts are also under way toward a molecular understanding of RNA-mediated events involving riboswitches and ribozymes, as well as protein-RNA recognition events impacting on disease syndromes. A new project addvesses structure-function studies of cytoplasmic metazoan nucleic acid sensors and their cyclic dinucleotide second messengers that activate the innate immune response. Other projects include higher-order DNA architectures and the DNA damage. Finally, our group also studies the molecular basis of glycosphingolipid and phospholipid  binding specificity.

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Pictured: Dinshaw Patel

Dinshaw Patel, PhD

Professor

Research Focus

Structural biologist Dinshaw Patel studies the structural biology of macromolecular recognition, including RNA catalysis, RNA interference, and bypass of DNA damage.
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Education

  • PhD, New York University

Lab Members