In our laboratory, we employ in-depth, state-of-the-art genome interrogation studies to understand the molecular origins and corresponding clonal relationships in cancer, as well as how these determine clinical phenotype and response to therapy. Our mission is to execute research that informs clinical practices in oncology and moves them forward. To achieve this, we conduct systematic research of large patient cohorts to extract genotype-outcome relationships, perform detailed clonal heterogeneity tracking studies in select clinical trial cohorts, and explore distinct genetic associations with emerging single-cell and iPS profiling methodologies.
Elli Papaemmanuil, PhD
Research FocusMolecular geneticist Elli Papaemmanuil performs systematic interrogations of well annotated clinical trial cohorts in leukemia and cancer to explore how the compound genetic and clonal architecture in patients leukemias and tumors dictate clinical phenotype, disease progression and clinical outcomes.
EducationPhD – University of London, London, England, UK
- Papaemmanuil E, Rapado I, Li Y, Potter NE, Wedge DC, Tubio J, Alexandrov LB, Van Loo P, Cooke SL, Marshall J, Martincorena I, Hinton J, Gundem G, van Delft FW, Nik-Zainal S, Jones DR, Ramakrishna M, Titley I, Stebbings L, Leroy C, Menzies A, Gamble J, Robinson B, Mudie L, Raine K, O’Meara S, Teague JW, Butler AP, Cazzaniga G, Biondi A, Zuna J, Kempski H, Muschen M, Ford AM, Stratton MR, Greaves M, Campbell PJ. RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia. Nat Genet. 2014 Feb;46(2):116-25. doi: 10.1038/ng.2874. Epub 2014 Jan 12. PubMed Central PMCID: PMC3960636. PubMed
- Gerstung M, Pellagatti A, Malcovati L, Giagounidis A, Porta MG, Jädersten M, Dolatshad H, Verma A, Cross NC, Vyas P, Killick S, Hellström-Lindberg E, Cazzola M, Papaemmanuil E, Campbell PJ, Boultwood J. Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes. Nat Commun. 2015 Jan 9;6:5901. doi: 10.1038/ncomms6901. PubMed Central PMCID: PMC4338540. PubMed
- European Hematology Association Young Investigator Award
- Cancer Research UK Career Development Award