We are interested in understanding the complexity of breast cancer behavior. Tumors are very heterogeneous in nature based on their morphology and expression of proteins which varies as a function of the location of a tumor and the relationship between a cancer cell and its neighboring cells.
Research FocusPhysician-scientist Jacqueline Bromberg focuses on aberrantly activated Stat3 and the mechanisms of Stat3-mediated transformation.
- MD, PhD, The University of North Carolina at Chapel Hill
- Peinado H, Alečković M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, García-Santos G, Ghajar C, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, Yuan J, Martins VR, Skog J, Kaplan RN, Brady MS, Wolchok JD, Chapman PB, Kang Y, Bromberg J, Lyden D. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2012 Jun;18(6):883-91. doi: 10.1038/nm.2753.
- Couto JP, Daly L, Almeida A , Knauf JA , Fagin JA, Sobrinho-Simões M , Lima J, Máximo V, Soares P , Lyden D, Bromberg J (co-corresponding authors). Stat3 negatively regulates thyroid tumorigenesis. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):E2361-70. doi: 10.1073/pnas.1201232109. Epub 2012 Aug 13.