The James Young Lab: Publications
Ratzinger G, Baggers J, de Cos MA, Yuan J, Reagan JL, Dao T, Munz C, Heller G, Young JW. Mature human Langerhans cells derived from CD34+ hematopoietic progenitors stimulate greater cytolytic T lymphocyte activity in the absence of bioactive IL-12p70, by either single peptide presentation or cross-priming, than do dermal-interstitial or monocyte-derived dendritic cells. J Immunol. 2004;173:2780-2791.
Munz C, Dao T, Ferlazzo G, de Cos MA, Goodman K, Young JW. Mature myeloid dendritic cell subsets have distinct roles for activation and viability of circulating human natural killer cells. Blood. 2005 Jan 1;105(1):266-73.
Boruchov AM, Heller G, Veri M-C, Bonvini E, Ravetch JV, Young JW. Activating and inhibitory IgG Fc receptors mediate opposing functions on human dendritic cells. J.Clin.Invest. 2005, 115: 2914-2923 (see also J.Clin.Invest. 2005, 115: 2585)
Yuan J, Latouche J-B, Hodges J, Houghton AN, Heller G, Sadelain M, Riviere I, Young JW. Langerhans-type dendritic cells genetically modified to express full-length antigen optimally stimulate CTLs in a CD4-dependent manner. J.Immunol. 2006, 176: 2357-2365.
Yuan J, Kendle R, Hodges J, Heller G, Sadelain M, Young JW*, Riviere I* (*equal contributors). Scalable expansion of potent genetically modified human Langerhans cells in a closed system for clinical applications. J. Immunotherapy 2007, 30: 634-643.
Strowig T, Gurer C, Ploss A, Liu YF, Arrey F, Sashihara J, Koo G, Rice CM, Young JW, Chadburn A, Cohen JI, Münz C. Priming of protective T cell responses against virus-induced tumors in mice with human immune system components. J.Exp.Med. 2009. 206: 1423-1434. (Epub 2009 Jun 1).
Chung DJ, Rossi M, Romano E, Ghith J, Antczak C, Munn DH, Young JW. Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand autologous regulatory T cells that are potent suppressors of T cell proliferation. Blood. 2009 114: 555-563. (Prepublished online as a Blood First Edition Paper on May 22, 2009.)
Romano E, Rossi M, Ratzinger G, de Cos MA, Chung DJ, Panageas K, Wolchok JD, Houghton AN, Chapman PB, Heller G, Yuan J, Young JW. Peptide-loaded Langerhans cells, despite increased IL15 secretion and T cell activation in vitro, elicit anti-tumor T cell responses comparable to peptide-loaded monocyte-derived dendritic cells in vivo. Clin Cancer Res. 17:1984-1997.
Betts BC, Abdel-Wahab O, Curran SA, St. Angelo ET, Koppikar P, Heller G, Levine RL, Young JW. 2011. Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell-stimulated T cells, yet preserves immunity to recall antigen. Blood. 118:5330-5339.
Betts BC, St. Angelo ET, Kennedy M, Young JW. 2011. Anti-IL6-receptor-alpha (tocilizumab) does not inhibit human monocyte-derived dendritic cell maturation or alloreactive T-cell responses. Blood. 118:5340-5343.