Epidemiology & Biostatistics

The Jian Carrot-Zhang Lab

Share
Back to top

Research

Jian Carrot-Zhang
Jian Carrot-Zhang, PhD
GSK Faculty Member

The Carrot-Zhang Lab started in 2022. We focus on developing cutting-edge computational methods to link the germline genome to the specific somatic phenotypes, in order to better characterize cancer risk and response to treatment mechanisms. Another focus of the lab is combining statistical modeling and large-scale, multiethnic clinical genomic cohorts to understand how cancer is impacted by genetic ancestry, with the goal of improving precision oncology for all. The group is also involved in Project GENIE (Genomics Evidence Neoplasia Information Exchange), a collaboration with The Cancer Genome Atlas (TCGA) and the American Association for Cancer Research (AACR), and has a strong interest in discovering new cancer drivers through whole-genome sequencing. More information about our research is available here.

Publications Highlights

Tumor sequencing of African ancestry reveals differences in clinically relevant alterations across common cancers. Jiagge E, Jin DX, Newberg JY, Perea-Chamblee T, Pekala KR, Fong C, Waters M, Ma D, Dei-Adomakoh Y, Erb G, Arora KS, Maund SL, Njiraini N, Ntekim A, Kim S, Bai X, Thomas M, van Eeden R, Hegde P, Jee J, Chakravarty D, Schultz N, Berger MF, Frampton GM, Sokol ES, Carrot-Zhang J. Cancer Cell. 2023 Nov 13;41(11):1963-1971.e3. Epub 2023 Oct 26. PMID: 37890492.

Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors. AH, Adib E, Abou Alaiwi S, El Zarif T, Groha S, Akl EW, Nuzzo PV, Mouhieddine TH, Perea-Chamblee T, Taraszka K, El-Khoury H, Labban M, Fong C, Arora KS, Labaki C, Xu W, Sonpavde G, Haddad RI, Mouw KW, Giannakis M, Hodi FS, Zaitlen N, Schoenfeld AJ, Schultz N, Berger MF, MacConaill LE, Ananda G, Kwiatkowski DJ, Choueiri TK, Schrag D, Carrot-Zhang J*, Gusev A*. Cancer Cell. 2022 Oct 10;40(10):1161-1172.e5. Epub 2022 Sep 29. PMID: 36179682; PMCID: PMC9559771.

Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations. Carrot-Zhang J, Soca-Chafre G, Patterson N, Thorner AR, Nag A, Watson J, Genovese G, Rodriguez J, Gelbard MK, Corrales-Rodriguez L, Mitsuishi Y, Ha G, Campbell JD, Oxnard GR, Arrieta O, Cardona AF, Gusev A, Meyerson M. Cancer Discov. 2021 Mar;11(3):591-598. Epub 2020 Dec 2. PMID: 33268447; PMCID: PMC7933062.

Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer. Carrot-Zhang J, Chambwe N, Damrauer JS, Knijnenburg TA, Robertson AG, Yau C, Zhou W, Berger AC, Huang KL, Newberg JY, Mashl RJ, Romanel A, Sayaman RW, Demichelis F, Felau I, Frampton GM, Han S, Hoadley KA, Kemal A, Laird PW, Lazar AJ, Le X, Oak N, Shen H, Wong CK, Zenklusen JC, Ziv E; Cancer Genome Atlas Analysis Network; Cherniack AD, Beroukhim R. Cancer Cell. 2020 May 11;37(5):639-654.e6.PMID: 32396860; PMCID: PMC7328015.

Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type. Witkowski L, Carrot-Zhang J, Albrecht S, Fahiminiya S, Hamel N, Tomiak E, Grynspan D, Saloustros E, Nadaf J, Rivera B, Gilpin C, Castellsagué E, Silva-Smith R, Plourde F, Wu M, Saskin A, Arseneault M, Karabakhtsian RG, Reilly EA, Ueland FR, Margiolaki A, Pavlakis K, Castellino SM, Lamovec J, Mackay HJ, Roth LM, Ulbright TM, Bender TA, Georgoulias V, Longy M, Berchuck A, Tischkowitz M, Nagel I, Siebert R, Stewart CJ, Arseneau J, McCluggage WG, Clarke BA, Riazalhosseini Y, Hasselblatt M, Majewski J, Foulkes WD.Nat Genet. 2014 May;46(5):438-43. Epub 2014 Mar 23. PMID: 24658002.

View All Publications

People

Jian Carrot-Zhang

Jian Carrot-Zhang, PhD

GSK Faculty Member

  • Computational Geneticist focused on germline-somatic interaction in multi-ethnic populations.
  • Postdoc: Dana-Farber Cancer Institute and Broad Institute
  • PhD, McGill University
  • Instructor, Harvard Medical School
[email protected]
Email Address
646-608-7645
Office Phone

Members

Tejiri Agbamu

GSK Graduate Student

Setor Amuzu

Henry and Alexia Fernandez Fellow

Xuechun Bai

Computational Biologist I

Nikolaos Dimitriou

Research Fellow

David Ma
David Ma

Computational Biologist I

Hussein Mohsen

Research Fellow

Leah Morales

‪NE WGS Student

Tomin Perea-Chamblee
Tomin Perea-Chamblee

Bioinformatics Software Engineer

Genesis Pineda

Senior Administrative Assistant

Lab Alumni
Kelly Pekala

Fellow

Lab Affiliations

Achievements

  • National Cancer Institute – K99 Pathway to Independence Award, “Understanding ancestral contribution to lung adenocarcinoma.” (Role: PI) (2021)
  • Banting Postdoctoral Fellowships Award, Canadian Institutes of Health Research (2019)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Computational Postdocs and Graduate Students

We are actively recruiting computational postdocs and graduate students interested in genetic ancestry, germline-somatic interaction and clinical genomics. Please send your CV to [email protected]

Apply now

Get in Touch