Allogeneic hematopoietic stem cell transplantation (HSCT) is an important therapy for a variety of malignancies, including leukemias, lymphomas, and myeloma. Several complications limit its use including relapse of malignancy, graft versus host disease, and prolonged immune depletion caused by the conditioning required for successful transplantation – all of which can lead to increased morbidity and mortality after allo-HSCT. My laboratory uses murine HSCT models to study clinically important problems in HSCT and to test novel therapeutic strategies which can be translated into clinical practice.
Marcel R. M. van den Brink, MD, PhD
Research FocusPhysician-scientist Marcel R. M. van den Brink studies the immunology of bone marrow transplantation.
EducationMD, PhD, Universiteit Leiden
- Caroline A. Lindemans*, Marco Calafiore*, Anna M. Mertelsmann*, Margaret H. O’Connor*, Jarrod A. Dudakov, Robert R. Jenq, Enrico Velardi, Lauren F. Young, Odette M. Smith, Gillian Lawrence, Juliet A. Ivanov, Ya-Yuan Fu, Shuichiro Takashima, Guoqiang Hua, Maria L. Martin, Kevin P. O’Rourke, Yuan-Hung Lo, Michal Mokry, Monica Romera-Hernandez, Tom Cupedo, Lukas Dow, Edward E. Nieuwenhuis, Noah F. Shroyer, Chen Liu, Richard Kolesnick, van den Brink MRM*, and Alan M. Hanash* (* These authors jointly supervised this work). Interleukin-22 Promotes Intestinal Stem Cell-Mediated Epithelial Regeneration. Nature 2015 Dec 24;528(7583):560-4. doi: 10.1038/nature16460. Epub 2015 Dec 9.
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