Allogeneic hematopoietic stem cell transplantation (HSCT) is an important therapy for a variety of cancers, including leukemias, lymphomas, and myeloma. Several complications limit its use, including relapse of malignancy, graft-versus-host disease, and prolonged immune depletion caused by the conditioning required for successful transplantation — all of which can lead to increased morbidity and mortality after allo-HSCT. My laboratory uses mouse HSCT models to study clinically important problems in HSCT and to test novel therapeutic strategies that can be translated into clinical practice.
Marcel R. M. van den Brink, MD, PhD
Research FocusPhysician-scientist Marcel R. M. van den Brink studies the immunology of bone marrow transplantation with a particular focus on intestinal microbiome and strategies to enhance thymus and immune reconstitution
EducationMD, PhD, Universiteit Leiden
- Caroline A. Lindemans*, Marco Calafiore*, Anna M. Mertelsmann*, Margaret H. O’Connor*, Jarrod A. Dudakov, Robert R. Jenq, Enrico Velardi, Lauren F. Young, Odette M. Smith, Gillian Lawrence, Juliet A. Ivanov, Ya-Yuan Fu, Shuichiro Takashima, Guoqiang Hua, Maria L. Martin, Kevin P. O’Rourke, Yuan-Hung Lo, Michal Mokry, Monica Romera-Hernandez, Tom Cupedo, Lukas Dow, Edward E. Nieuwenhuis, Noah F. Shroyer, Chen Liu, Richard Kolesnick, van den Brink MRM*, and Alan M. Hanash* (* These authors jointly supervised this work). Interleukin-22 Promotes Intestinal Stem Cell-Mediated Epithelial Regeneration. Nature 2015 Dec 24;528(7583):560-4. doi: 10.1038/nature16460. Epub 2015 Dec 9.
- Velardi E, Tsai JJ, Holland AM, Wertheimer T, Yu VW, Zakrzewski JL, Tuckett AZ, Singer NV, West ML, Smith OM, Young LF, Kreines FM, Levy ER, Boyd RL, Scadden DT, Dudakov JA, van den Brink MRM. Sex steroid blockade enhances thymopoiesis by modulating Notch signaling. The Journal of Experimental Medicine . 2014 Nov 17;211(12):2341-9. doi: 10.1084/jem.20131289. Epub 2014 Oct 20.