Almost every cell in an organism contains the identical DNA sequence; yet different tissues transcribe unique sets of genes. Differences in transcription are mediated in part through epigenetic marks including DNA methylation and histone modifications. Epigenetic regulation is also important for heritable silencing of transcription at transposons, repeated sequences and the inactive X chromosome. Altered epigenetic profiles lead to abnormal development and are almost always detected in cancer genomes. We are interested in understanding the mechanisms of epigenetic regulation and their roles in vertebrate development with a primary focus on the DNA modification, 5-methylcytosine.
Mary Goll, PhD
Research FocusDevelopmental biologist Mary Goll investigates the mechanisms of epigenetic regulation and its role in development using zebrafish as a model system.
- PhD, Columbia University
- Akitake CM, Macurak M, Halpern ME, Goll MG. Transgenerational analysis of transcriptional silencing in zebrafish. Dev Biol. 2011 Apr 15;352(2):191-201. doi: 10.1016/j.ydbio.2011.01.002. Epub 2011 Jan 9.
- Hu G, Goll MG, Fisher S. ΦC31 integrase mediates efficient cassette exchange in the zebrafish germline. Dev Dyn. 2011 Sep;240(9):2101-7. doi: 10.1002/dvdy.22699. Epub 2011 Jul 29.
- Basil O’Connor Scholar, March of Dimes (2012-2014)
- Louis V. Gerstner, Jr. Young Investigators Award, Memorial Sloan Kettering Cancer Center (2011-2014)
- Postdoctoral Fellow, Damon Runyon Cancer Research Foundation (2007-2009)
- Deans Award for Research Excellence, Columbia University (2006)