More About The Alexandra Joyner Lab Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.

Alberto Roselló-Díez, PhD

Postdoctoral Research Fellow

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Education and Training

June 2012  - Present

Research Fellow, SKI Developmental Biology Program, Joyner Lab

February 2008 - June 2012

Predoctoral/Postdoctoral Researcher, CNIC, Madrid

December 2010

PhD in Molecular Biology, Universidad Autónoma de Madrid

September 2005 - April 2007

Predoctoral Researcher, National Center for Biotechnology, Madrid

June 2005

Masters in Biochemistry, Universidad de Zaragoza (Spain)

Research Interests

My main goal is to study why our limbs are so equal in size, which is a key feature for efficient locomotion and interaction with the environment. Growth of the long bones takes place at the so-called growth plate (GP), which is capable of considerable regulation to compensate for transient growth anomalies (a phenomenon known as catch-up growth (CUG)); however, no existing model can explain all of the observed situations. A systemic, hormone-based model fails to explain experimental CUG occurring only in one GP, while an alternative model in which the total number of cell cycle rounds is autonomously regulated at each GP cannot explain the most common type of CUG in which the growth rate increases beyond the normal levels for any stage. Thus, we hypothesize that there is an active left-right communication system capable of comparing bone size on both sides of the body and triggering local compensation mechanisms at the level of each individual GP. The potential size-sensing and size-compensation mechanisms will be studied in two situations: 1) Normal growth scenario in which we will alter the levels of candidate molecules pharmacologically and genetically, focusing on their effect on left-right asymmetry. 2) A unilateral CUG scenario using new genetic tools to transiently increase or decrease size in only one side of the body, allowing to compare the response of left and right limbs.