Alexander Lesokhin, MD

Assistant Member

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Alexander Lesokhin, MD

Assistant Attending Physician

Office Phone

212-639-3069

Lab Phone

646-888-2585

My research is focused on mechanisms of immune evasion facilitated by a population of myeloid lineage cells called myeloid derived suppressor cells (MDSC). This is a heterogeneous group of cells defined by the myeloid lineage marker CD11b and the ability to suppress T cell function. I have established a system to assay MDSC function in vitro and I have characterized two mouse strains where specific subsets of monocyte/macrophage cells can be traced and selectively depleted. Using these reagents, I aim to characterize the role of myeloid cells in priming or inhibiting tumor antigen specific immunity. In addition, together with the Immune Monitoring Facility, I am working to characterize MDSC populations in humans with cancer. Currently we are validating a panel of flow cytometric markers to screen human samples from healthy donors and patients enrolled in a number of clinical trials ongoing at Memorial Sloan Kettering Cancer Center.

I have a specific interest in developing innovative ways to use the immune system to treat cancer.  My laboratory research is focused on the characterization of myeloid derived suppressor cells (MDSC) and the implications of these cells for the development of adaptive immune responses against melanoma and other cancers.

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Alexander Lesokhin discloses the following relationships and financial interests:

  • Amgen
    Provision of Services
  • Boehringer Ingelheim
    Provision of Services
  • Bristol-Myers Squibb
    Provision of Services
  • GenMab
    Provision of Services
  • Janssen Biotech, Inc.
    Provision of Services
  • Serametrix
    Intellectual Property Rights

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This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

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