More About The Marcel van den Brink Lab Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.

Amanda Holland, PhD

Research Fellow

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Yale University, New Haven, Connecticut

Currently: Scientific Officer at University of Birmingham

Poor T cell reconstitution following hematopoietic stem cell transplantation (HSCT) leads to susceptibility to tumor relapse and opportunistic infections. We are studying mechanisms contributing to T cell reconstitution following transplant, as well as methods to improve immune function in this setting.

We have previously demonstrated that adoptive transfer of in vitro-generated T cell precursors at the time of transplant leads to enhanced thymocyte and peripheral T cell numbers, resulting in significant anti-tumor and antimicrobial immunity post-HSCT. Our current work focuses on identifying extrathymic sites of T cell development following HSCT, as well as mechanisms of T cell precursor trafficking to the thymus and extrathymic sites. We are also investigating the role of KGF in post-transplant T cell development and reconstitution with T cell precursors.

Finally, we are utilizing lentiviral vectors to confer superior immune reconstitution capability on in vitro-generated T cell precursors.