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Deniz Simsek, PhD

Graduate Student



Dr. Maria Jasin


Weill Cornell Medical College

Current Position: Research Fellow at Stanford School of Medicine in Stanford, California


DNA ligase III: a spotty presence in eukaryotes, but an essential function where tested.

Simsek D, Jasin M. Cell Cycle. 2011 Nov 1;10(21):3636-44. doi: 10.4161/cc.10.21.18094. Review. PMID:22041657

DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation.

Simsek D, Brunet E, Wong SY, Katyal S, Gao Y, McKinnon PJ, Lou J, Zhang L, Li J, Rebar EJ, Gregory PD, Holmes MC, Jasin M. PLoS Genet. 2011 Jun;7(6):e1002080. doi: 10.1371/journal.pgen.1002080. PMID:21655080

Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair.

Simsek D, Furda A, Gao Y, Artus J, Brunet E, Hadjantonakis AK, Van Houten B, Shuman S, McKinnon PJ, Jasin M.

Nature. 2011 Mar 10;471(7337):245-8. doi: 10.1038/nature09794. PMID:21390132

Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation. Simsek D, Jasin M. Nat Struct Mol Biol. 2010 Apr;17(4):410-6. doi: 10.1038/nsmb.1773. PMID:20208544

Chromosomal translocations induced at specified loci in human stem cells.

Brunet E, Simsek D, Tomishima M, DeKelver R, Choi VM, Gregory P, Urnov F, Weinstock DM, JasinM.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10620-5. doi: 10.1073/pnas.0902076106. PMID: 19549848