Konrad H. Stopsack, MD, MPH

Research Associate

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Konrad H. Stopsack

Education

MD, University of Freiburg; MPH, Harvard School of Public Health; Internal Medicine Residency, Mayo Clinic Rochester

I am a molecular epidemiologist with a background as a board-certified internal medicine physician. My main research interest is how potentially modifiable exposures cause solid tumors through genomic heterogeneity and influence cancer progression. I am passionate about combining state-of-the-art genomics and well-defined observational studies in order to inform primary prevention, risk stratification, and biomarker-guided treatment. My methodologic and teaching interests include the application of epidemiologic methods to biomarker and clinical studies.

As a Research Associate with Dr. Philip Kantoff’s group, I lead highly interdisciplinary and collaborative research projects across epidemiology, genomics, pathology, bioinformatics, and clinical medicine, with additional experimental validation in cell culture systems. I am the principal investigator of a 2017 Prostate Cancer Foundation Young Investigator Award and a 2018 Department of Defense Early-Investigator Research Award.

As an example of my work on genomic heterogeneity of prostate cancer, I showed that tumors that are very active in synthesizing cholesterol are more likely to metastasize. These results support that cholesterol-lowering statin medications could indeed improve patients’ prognosis, and cholesterol synthesis activity may be a suitable predictive biomarker for clinical trials. In another research lead, I developed methodology to measure the extent of aneuploidy—aberrant numbers of chromosomes—in the tumor transcriptome. We showed that aneuploidy is a strong risk factor for progression to lethal disease, suggesting a potential to better understand the etiology of lethal tumors and to identify therapeutic targets in prostate cancer and beyond.

Publications

Stopsack KH, Whittaker CA, Gerke TA, Loda M, Kantoff PW, Mucci LA, Amon A. Aneuploidy drives lethal progression in prostate cancer. Proc Natl Acad Sci U S A. 2019. Journal Article

Stopsack KH, Gerke T, Tyekucheva S, Mazzu YZ, Lee GM, Chakraborty G, Abida W, Mucci LA, Kantoff PW. Low Expression of the Androgen-Induced Tumor Suppressor Gene PLZF and Lethal Prostate Cancer. Cancer Epidemiol Biomarkers Prev. 2019;28(4):707-714. Journal Article

Stopsack KH, Gonzalez-Feliciano AG, Peisch S, Downer MK, Gage RA, Finn S, Lis RT, Graff RE, Pettersson A, Pernar CH, Loda M, Kantoff PW, Ahearn TU, Mucci LA, on behalf of the Transdisciplinary Prostate Cancer Partnership (ToPCaP). A prospective study of aspirin use and prostate cancer risk by TMPRSS2:ERG status. Cancer Epidemiol Biomarkers Prev. 2018;27(10):1231-1233. Journal Article | Free Full text

Stopsack KH, Gerke TA, Andrén O, Andersson SO, Giovannucci EL, Mucci LA, Rider JR. Cholesterol uptake and regulation in high-grade and lethal prostate cancers. Carcinogenesis. 2017;38(8):806-11. Journal Article | Free Full text

Stopsack KH, Gerke TA, Sinnott JA, Penney KL, Tyekucheva S, Sesso HD, Andersson SO, Andrén O, Cerhan JR, Giovannucci EL, Mucci LA, Rider JR. Cholesterol metabolism and prostate cancer lethality. Cancer Res. 2016;76(16):4785-90. Journal Article | Free Full text

View a full listing of Konrad H. Stopsack’s journal articles.