N. Sumru Bayin, Ph.D.

Postdoctoral Research Fellow

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Start Year


Education and Training
March 2016-Present
Research Fellow, SKI Developmental Biology Program, Joyner Lab

September 2010-January 2016
PhD in Stem Cell Biology, New York University, Sackler Institute of Biomedical Sciences

September 2008- July 2010
MSc in Molecular Biology and Genetics, Bilkent University, Ankara, Turkey

September 2004 – June 2008
BSc in Molecular Biology and Genetics, Bilkent University, Ankara, Turkey

Research Interests

Stem cells are key players in development, tissue homeostasis, repair and tumorigenesis. However, the signaling queues that regulate stem cell self-renewal and differentiation under these various processes are not fully understood. Using the mouse cerebellum as a model system, my research in Joyner lab aims to provide insights into our understanding of: 1) molecular mechanism that regulate self-renewal and differentiation of stem cells in the mouse cerebellum upon injury and that contribute to repair, and 2) the role of these specialized stem cells play in the formation of medulloblastoma, the most common malignant brain tumor in children.



  1. Bayin, N. S., Modrek, A., Dietrich, A., Abel, T., Song, H.-R., Schober, M., Buchholz, C., Chao, M., & Placantonakis, D. G. 2014. Selective Lentiviral Gene Delivery into CD133- expressing human Glioblastoma Stem Cells. PLoSOne 9:e116114. DOI: 10.1371/journal.pone.0116114. 

  2. Basu-Roy, U., Bayin, N. S., Rattanakorn, K., Han, E., Placantonakis, D. G., Mansukhani, A., & Basilico, C. 2015. SOX2 Antagonizes the Hippo Pathway to Maintain Stemness in Cancer Cells. Nature Communications Apr 2;6:6411. doi: 10.1038/ncomms7411. 

  3. Bayin, N. S., & Placantonakis, D. G. 2014. Heterogeneity and Diversity of Cancer Stem Cells in Glioblastoma. International Journal of Stem Cell Research and Therapy 1:001e. 

  4. Murtha, M., Strino, F. Tokcaer-Keskin, Z., Bayin, N. S., Shalabi, D., Xi, X, Kluger, Y., Dailey, L., Comparative FAIRE-Seq Analysis Reveals Distinguishing Features of the Chromatin Structure of Ground State and Primed Pluripotent Cells. Stem Cells 33(2):378-91. doi: 10.1002/stem.1871. 

  5. Bayin, N. S., Modrek, A. S. & Placantonakis, D. G. 2014. Glioblastoma Stem Cells: Molecular Characteristics and Therapeutic Implications. World Journal of Stem Cells 6:230- 238. Invited Review 

  6. Modrek, A. S., Bayin, N. S. & Placantonakis, D. G. 2014. Stem cells as the cell of origin in glioma. World Journal of Stem Cells 6:43-52. 

  7. Labit, H., Fujimitsu, K., Bayin, N. S., Takaki, T., Gannon, J. and Yamano, H. ’Dephosphorylation of Cdc20 is required for its C-box-dependent activation of the APC/C’, The EMBO journal. EMBO J. 31(15):3351-62.