I am part of the immunology program at Weill Cornell Graduate School. Due to natural safeguards to protect against autoimmunity tumor-self antigen specific T cells are eliminated from our immune repertoire and if present may be relatively scarce. I am interested in how the precursor frequency of these tumor antigen specific CD4+ T cells shapes the effectiveness of an anti-tumor immune response. To investigate this I have developed a model system in which precursor number can be manipulated in mice bearing implantable melanoma tumors through the adoptive transfer of tumor specific T cells of known specificity.
PhD Weill Cornell Student