Robert Bowman, BA

Graduate Student

Pictured: Robert Bowman

Lab Phone

646-888-2058

Email

bowmanr@sloankettering.edu

Mentor

Johanna Joyce

Start Year

2010

Education

BA, Vanderbilt University

I am interested in understanding the role of the tumor microenvironment in disease progression. My goal is to understand how tumor cells educate immune cells to generate pro-tumorigenic phenotypes. A life doing research such as this can be very rewarding. The flexibility in hours and work schedule can be wonderful but can also lead to very long days. Collaborating with friends and colleagues at Gerstner Sloan Kettering is easily the best part. I find that most of my really good experiments benefited from seeking out friends who taught me how a technique worked or helped me utilize a biological system to address my question. These interactions turn what can be an isolating job into a rich, fun experience.

Fellowships

Ruth L. Kirschstein Predoctoral Individual National Research Service Award - NIH F31 (2012-2016)

Geoffrey Beene Graduate Student Fellowship (2011-2012)

Publications

Akkari L, Gocheva V, Quick ML, Kester JC, Spencer AK, Garfall AL, Bowman RL, Joyce JA. (2016) Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer. Genes Dev.,  30, 220-32. PMCID: PMC4719311.

Sansone P, Ceccarelli C, Berishaj M, Chang Q, Rajasekhar VK, Perna F, Bowman RL, Vidone M, Daly L, Nnoli J, Santini D, Taffurelli M, Shih NN, Feldman M, Mao JJ, Colameco C, Chen J, DeMichele A, Fabbri N, Healey JH, Cricca M, Gasparre G, Lyden D, Bonafé M, Bromberg J. (2016)  Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer.  Nat Commun.,  7, 10442. PMCID: PMC4748123.

Pyonteck, S., Akkari, L., Schuhmacher, A., Bowman, R., Sevenich, L., Quail, D., Olson, O., Quick, M., Huse, J., Teijeiro, V., Setty, M., Leslie, C., Oei, Y., Pedraza, A., Zhang, J., Brennan, C., Sutton, J., Holland, E., Daniel, D., and Joyce, J. (2013) CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med. 19, 1264-1272. PMID: 24056773; PMCID: PMC38440724.

Miller, J., Ganat, Y., Kishinevsky, S., Bowman, R., Liu, B., Tu, E., Mandal, P., Vera, E., Shim, J., Kriks, S., Taldone, T., Fusaki, N., Tomishima, M., Krainc, D., Milner, T., Rossi, D., and Studer, L. (2013) Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging. Cell Stem Cell, 13, 691-705. PMID: 24315443.

Bowman, R., Joyce J. (2014) Therapeutic targeting of tumor-associated macrophages and microglia in glioblastoma. Immunotherapy, 6, 663-666. PMID: 25041027.

Sevenich L, Bowman R, Mason S, Quail D, Rapaport F, Elie B, Brogi E, Brastianos P, Hahn W, Holsinger L, Massagué J, Leslie C, Joyce J. (2014) Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S. Nat Cell Biol., 16, 876-88. PMCID: PMC4249762.

Bowman RL, Xiong Y, Kirsten JH, Singleton CK. (2011) eIF2a kinases control chalone production in Dictyostelium discoideum.  Eukaryot Cell, 10, 494-501. PMCID: PMC3127634.