Roberta Zappasodi, PhD

Research Scholar

Roberta Zappasodi, PhD

Research Scholar

Lab Phone

646-888-2322

E-mail

zappasor@mskcc.org

I am investigating how co-stimulation, with agonist anti-GITR, and checkpoint blockade, with antagonist anti-CTLA4 monoclonal antibodies affect suppressive T cells in tumor microenvironment. In particular, I am involved in the study of the mechanisms of action responsible for the success or failure of these antibodies in preclinical mouse models. In addition, I am also investigating the induction of immune responses to self-antigens using a vaccine based on Alphavirus-like replicon particles (VRP) alone or in combination with immune modulation