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Sadna Budhu, PhD

Research Fellow

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I developed a three-dimensional collagen-fibrin gel system to examine tumor specific T cell killing. Coupled with an equation (bt=b0e-kpt+gt) that accurately models T cell killing of melanoma cells, collagen-fibrin gels represent a quantitative model for assessing the cytolytic activity of antigen-specific T cells. My research focuses on quantitatively assessing the role of radiation, chemotherapy, immune modulation and cancer specific vaccines on the effector T cell responses to tumor antigens using breast cancer and melanoma as model systems.