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My research focuses on transcriptional and post-transcriptional regulation of key genes for castration resistance prostate cancer (CRPC).
Hovhannisyan H, Zhang Y, Hassan MQ, Wu H, Glackin C, Lian JB, Stein JL, Montecino M, Stein GS van Wijnen AJ. Two Stable Genomic Protein/DNA Interaction Domains Support Epigenetic and Bone-Specific Regulation of the Runt-related Transcription Factor Runx2. J Cell Physiol, 2012 2013 228(2):313-21.
Zhang Y, Xie RL, Gordon J, LeBlanc K, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Control of mesenchymal lineage progression by microRNAs targeting the skeletal gene regulators Trps1 and Runx2. J Biol Chem, 2012 22;287(26):21926-35.
Lian JB, Stein GS, van Wijnen AJ, Stein JL, Hassan MQ, Gaur T, Zhang Y. MicroRNA control of bone formation and homeostasis. Nat Rev Endocrinol 2012 31;8(4):212-217.
Zhang Y, Xie RL, Stein JL, Lian JB, van Wijnen AJ, Stein GS. A program of microRNAs controls osteogenic and chondrogenic lineage progressions by targeting transcription factors Runx2. Proc Natl Acad Sci U S A. 2011 108(24):9863-9868.
Zhang Y, Hassan MQ, Xie RL, Hawse JR, Spelsberg TC, Montecino M, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences (Y-repeats). J Biol Chem. 2009 284(5):3125-3135.
Teplyuk NM, Zhang Y, Lou Y, Hawse JR, Hassan MQ, Teplyuk VI, Pratap J, Galindo M, Stein JL, Stein GS, Lian JB, van Wijnen AJ. The osteogenic transcription factor Runx2 controls genes involved in sterol/steroid metabolism, including Cyp11a1 in osteoblasts. Mol Endocrinol. 2009 23(6):849-861.
Xie RL, Medina R, Zhang Y, Hussain S, Colby J, Ghule P, Sundarajan S, Keeler M, Liu LJ, van der Deen M, Mitra P, Lian J, Rivera J, Jones SN, Stein JL, van Wijnen AJ, Stein GS. The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles. Proc Natl Acad Sci U S A. 2009 106(30):12359-12364.