The major goal of our research is to understand how the number of an important cellular organelle — the centrosome — is maintained during cell division and development. The centrosome is the main organizer of the microtubule cytoskeleton, exerting spatial and temporal regulation over the formation of microtubule polymers. The centrosome has profound effects on mitotic spindle formation; therefore, regulation of centrosome duplication is fundamental to genome stability.
- Wang WJ, Acehan D, Kao CH, Jane WN, Uryu K, Tsou MF. (2015). De novo centriole formation in human cells is error-prone and does not require SAS-6 self-assembly. Elife. 4. pii: e10586. [Epub ahead of print]
- Yang TT, Su J, Wang WJ, Craige B, Witman GB, Tsou MF, Liao JC. (2015). Superresolution Pattern Recognition Reveals the Architectural Map of the Ciliary Transition Zone. Sci Rep. 5:14096.